Glatiramer acetate reduces the proportion of new MS lesions evolving into "black holes"

M. Filippi, M. Rovaris, M. A. Rocca, M. P. Sormani, J. S. Wolinsky, G. Comi

Research output: Contribution to journalArticlepeer-review

Abstract

The authors evaluated whether glatiramer acetate (GA) modifies the severity of tissue damage in 1,722 new lesions from 239 patients with MS enrolled in a placebo-controlled trial monitored with monthly cerebral MRI. The percentage of new lesions that evolved into "black holes" was lower in GA-treated than in placebo patients on scans at 7 (18.9 and 26.3%; p = 0.04) and 8 (15.6 and 31.4%; p = 0.002) months after lesion appearance. GA has a favorable effect on tissue disruption in MS lesions once they are formed.

Original languageEnglish
Pages (from-to)731-733
Number of pages3
JournalNeurology
Volume57
Issue number4
Publication statusPublished - Aug 28 2001

ASJC Scopus subject areas

  • Neuroscience(all)

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