Glaucoma: An Overview

Sergio Claudio Saccà, Cristina Cartiglia, Alberto Izzotti

Research output: Chapter in Book/Report/Conference proceedingChapter


Glaucoma is a disease known since the Hippocrates time. This term indicates a number of neurodegenerative diseases having in common a progressive optical atrophy resulting from the apoptosis of retinal ganglion cells, axon atrophy, and degeneration extending to the visual areas of the brain cortex, finally leading to the characteristic optical-cup neuropathy and to irreversible visual loss. The action of many factors including aging, genetic predisposition, and exogenous environmental and endogenous factors, is necessary for glaucoma development. In addition to ganglion cell loss, most glaucoma types are characterized by a high intraocular pressure. This is due to the damage occurring in the trabecular meshwork, a key region in the pathogenesis of high-pressure glaucoma. In normal-pressure glaucoma, pathogenesis is different with vascular factors playing a remarkably important role.

Original languageEnglish
Title of host publicationHandbook of Nutrition, Diet and the Eye
PublisherElsevier Inc.
Number of pages12
ISBN (Print)9780124046061, 9780124017177
Publication statusPublished - Apr 10 2014


  • Endothelial dysfunction
  • Glaucoma
  • High-tension glaucoma
  • Intraocular pressure
  • Mitochondria
  • Normal tension glaucoma
  • Oxidative stress
  • Trabecular meshwork

ASJC Scopus subject areas

  • Medicine(all)


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