Glia-derived exosomes: Promising therapeutic targets

He Li; Yin Luo; Luojiang Zhu; Weilong Hua; Yongxin Zhang; Hongjian Zhang; Lei Zhang; Zifu Li; Pengfei Xing; Yongwei Zhang; Bo Hong; Pengfei Yang; Jianmin Liu

doi:10.1016/j.lfs.2019.116951

Glia-derived exosomes: Promising therapeutic targets

He Li, Yin Luo, Luojiang Zhu, Weilong Hua, Yongxin Zhang, Hongjian Zhang, Lei Zhang, Zifu Li, Pengfei Xing, Yongwei Zhang, Bo Hong, Pengfei Yang, Jianmin Liu

Research output: Contribution to journal › Review article › peer-review

Abstract

Glia is an important component of the nervous system that is involved in neurotransmitter uptake, signal transduction, myelin synthesis, neurodevelopment, and immune response. Exosomes are extracellular vesicles that are secreted from certain types of cells, and are known to mediate glia function. Glia-derived exosomes (GDEs) can transport proteins, nucleotides and cellular waste, and exert both protective and toxic effects on the nervous system. GDEs promote glia-neuron communication, anti-stress responses, anti-inflammation and neurite outgrowth, and may also be involved in neurological disease such as glioma, glioblastoma, Alzheimer's disease, Parkinson disease and neuronal HIV infections. This review summarizes the current research on GDEs and their functions, with emphasis on their therapeutic potential.

Original language	English
Pages (from-to)	116951
Journal	Life Sciences
Volume	239
DOIs	https://doi.org/10.1016/j.lfs.2019.116951
Publication status	Published - Dec 15 2019
Externally published	Yes

Keywords

Animals
Cell Communication/physiology
Central Nervous System/metabolism
Exosomes/metabolism
Humans
Neuroglia/metabolism
Neurons
Neurotransmitter Agents
Signal Transduction

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title = "Glia-derived exosomes: Promising therapeutic targets",

abstract = "Glia is an important component of the nervous system that is involved in neurotransmitter uptake, signal transduction, myelin synthesis, neurodevelopment, and immune response. Exosomes are extracellular vesicles that are secreted from certain types of cells, and are known to mediate glia function. Glia-derived exosomes (GDEs) can transport proteins, nucleotides and cellular waste, and exert both protective and toxic effects on the nervous system. GDEs promote glia-neuron communication, anti-stress responses, anti-inflammation and neurite outgrowth, and may also be involved in neurological disease such as glioma, glioblastoma, Alzheimer's disease, Parkinson disease and neuronal HIV infections. This review summarizes the current research on GDEs and their functions, with emphasis on their therapeutic potential.",

keywords = "Animals, Cell Communication/physiology, Central Nervous System/metabolism, Exosomes/metabolism, Humans, Neuroglia/metabolism, Neurons, Neurotransmitter Agents, Signal Transduction",

author = "He Li and Yin Luo and Luojiang Zhu and Weilong Hua and Yongxin Zhang and Hongjian Zhang and Lei Zhang and Zifu Li and Pengfei Xing and Yongwei Zhang and Bo Hong and Pengfei Yang and Jianmin Liu",

year = "2019",

month = dec,

day = "15",

doi = "10.1016/j.lfs.2019.116951",

language = "English",

volume = "239",

pages = "116951",

journal = "Life Sciences",

issn = "0024-3205",

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TY - JOUR

T1 - Glia-derived exosomes

T2 - Promising therapeutic targets

AU - Li, He

AU - Luo, Yin

AU - Zhu, Luojiang

AU - Hua, Weilong

AU - Zhang, Yongxin

AU - Zhang, Hongjian

AU - Zhang, Lei

AU - Li, Zifu

AU - Xing, Pengfei

AU - Zhang, Yongwei

AU - Hong, Bo

AU - Yang, Pengfei

AU - Liu, Jianmin

PY - 2019/12/15

Y1 - 2019/12/15

N2 - Glia is an important component of the nervous system that is involved in neurotransmitter uptake, signal transduction, myelin synthesis, neurodevelopment, and immune response. Exosomes are extracellular vesicles that are secreted from certain types of cells, and are known to mediate glia function. Glia-derived exosomes (GDEs) can transport proteins, nucleotides and cellular waste, and exert both protective and toxic effects on the nervous system. GDEs promote glia-neuron communication, anti-stress responses, anti-inflammation and neurite outgrowth, and may also be involved in neurological disease such as glioma, glioblastoma, Alzheimer's disease, Parkinson disease and neuronal HIV infections. This review summarizes the current research on GDEs and their functions, with emphasis on their therapeutic potential.

AB - Glia is an important component of the nervous system that is involved in neurotransmitter uptake, signal transduction, myelin synthesis, neurodevelopment, and immune response. Exosomes are extracellular vesicles that are secreted from certain types of cells, and are known to mediate glia function. Glia-derived exosomes (GDEs) can transport proteins, nucleotides and cellular waste, and exert both protective and toxic effects on the nervous system. GDEs promote glia-neuron communication, anti-stress responses, anti-inflammation and neurite outgrowth, and may also be involved in neurological disease such as glioma, glioblastoma, Alzheimer's disease, Parkinson disease and neuronal HIV infections. This review summarizes the current research on GDEs and their functions, with emphasis on their therapeutic potential.

KW - Animals

KW - Cell Communication/physiology

KW - Central Nervous System/metabolism

KW - Exosomes/metabolism

KW - Humans

KW - Neuroglia/metabolism

KW - Neurons

KW - Neurotransmitter Agents

KW - Signal Transduction

U2 - 10.1016/j.lfs.2019.116951

DO - 10.1016/j.lfs.2019.116951

M3 - Review article

C2 - 31626787

VL - 239

SP - 116951

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

ER -