TY - JOUR
T1 - Glia-derived exosomes
T2 - Promising therapeutic targets
AU - Li, He
AU - Luo, Yin
AU - Zhu, Luojiang
AU - Hua, Weilong
AU - Zhang, Yongxin
AU - Zhang, Hongjian
AU - Zhang, Lei
AU - Li, Zifu
AU - Xing, Pengfei
AU - Zhang, Yongwei
AU - Hong, Bo
AU - Yang, Pengfei
AU - Liu, Jianmin
N1 - Copyright © 2019 Elsevier Inc. All rights reserved.
PY - 2019/12/15
Y1 - 2019/12/15
N2 - Glia is an important component of the nervous system that is involved in neurotransmitter uptake, signal transduction, myelin synthesis, neurodevelopment, and immune response. Exosomes are extracellular vesicles that are secreted from certain types of cells, and are known to mediate glia function. Glia-derived exosomes (GDEs) can transport proteins, nucleotides and cellular waste, and exert both protective and toxic effects on the nervous system. GDEs promote glia-neuron communication, anti-stress responses, anti-inflammation and neurite outgrowth, and may also be involved in neurological disease such as glioma, glioblastoma, Alzheimer's disease, Parkinson disease and neuronal HIV infections. This review summarizes the current research on GDEs and their functions, with emphasis on their therapeutic potential.
AB - Glia is an important component of the nervous system that is involved in neurotransmitter uptake, signal transduction, myelin synthesis, neurodevelopment, and immune response. Exosomes are extracellular vesicles that are secreted from certain types of cells, and are known to mediate glia function. Glia-derived exosomes (GDEs) can transport proteins, nucleotides and cellular waste, and exert both protective and toxic effects on the nervous system. GDEs promote glia-neuron communication, anti-stress responses, anti-inflammation and neurite outgrowth, and may also be involved in neurological disease such as glioma, glioblastoma, Alzheimer's disease, Parkinson disease and neuronal HIV infections. This review summarizes the current research on GDEs and their functions, with emphasis on their therapeutic potential.
KW - Animals
KW - Cell Communication/physiology
KW - Central Nervous System/metabolism
KW - Exosomes/metabolism
KW - Humans
KW - Neuroglia/metabolism
KW - Neurons
KW - Neurotransmitter Agents
KW - Signal Transduction
U2 - 10.1016/j.lfs.2019.116951
DO - 10.1016/j.lfs.2019.116951
M3 - Review article
C2 - 31626787
VL - 239
SP - 116951
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
ER -