Gliadin immune reactivity is associated with overt and latent enteropathy in relatives of celiac patients

Ginoroberto Corazza, Rodolfo A. Valentini, Magda Frisoni, Umberto Volta, Giovanni Corrao, Francesco B. Bianchi, Giovanni Gasbarrini

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Abstract

Antigliadin antibodies have been widely used in the screening of celiac disease. Using this test, candidates for jejunal biopsy were selected from 328 first-degree relatives of 128 adult celiac patients. All relatives geographically available were willing to participate in the study. Twenty-one turned out to be positive for antigliadin antibodies, and in 13 jejunal histology was consistent with celiac disease. In the remaining 8, the morphometric evaluation of jejunal biopsy specimens showed a mean surface to volume ratio that, although in the normal range, was significantly lower than that of other 10 relatives negative for antigliadin antibodies and 16 biopsied controls. It was concluded that antigliadin antibody testing is a valuable method for the screening of celiac disease among family members and that relatives with genetically predisposed gliadin sensitivity, without gross histological lesions but with minor morphometric abnormalities of the jejunal mucosa, may be regarded as subjects with latent celiac disease.

Original languageEnglish
Pages (from-to)1517-1522
Number of pages6
JournalGastroenterology
Volume103
Issue number5
Publication statusPublished - 1992

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ASJC Scopus subject areas

  • Gastroenterology

Cite this

Corazza, G., Valentini, R. A., Frisoni, M., Volta, U., Corrao, G., Bianchi, F. B., & Gasbarrini, G. (1992). Gliadin immune reactivity is associated with overt and latent enteropathy in relatives of celiac patients. Gastroenterology, 103(5), 1517-1522.