Glial fibrillary acidic protein and vimentin in the experimental glial reaction of the rat brain

Davide Schiffer, Maria Teresa Giordana, Antonio Migheli, Giorgio Giaccone, Stefano Pezzotta, Alessandro Mauro

Research output: Contribution to journalArticlepeer-review

Abstract

Glial reaction has been studied in the rat by the immunohistochemical demonstration of glial fibrillary acidic protein (GFAP) and vimentin (VIM) in two experimental conditions. The first was represented by a necrotic cerebral lesion obtained by laser irradiation and the second by the development of experimental tumors induced by transplacental ethylnitrosourea. Reactive astrocytes develop not only in the proximity of the lesion but also distant from it. The intensity of the glial response seems to depend upon the normal distribution of astrocytes and the perilesional edema. GFAP decorates all the reactive astrocytes, whereas VIM is positive only in those at the edges of the lesion. The significance of the different responses in the two models and between the two intermediate filaments is discussed.

Original languageEnglish
Pages (from-to)110-118
Number of pages9
JournalBrain Research
Volume374
Issue number1
DOIs
Publication statusPublished - May 21 1986

Keywords

  • glial fibrillary acidic protein
  • glial reaction
  • rat brain
  • vimentin

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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