Glial fibrillary acidic protein (GFAP) in human cerebral tumors. An immunohistochemical study.

D. Schiffer, M. T. Giordana, A. Mauro, A. Migheli

Research output: Contribution to journalArticle

Abstract

Glial fibrillary acidic protein (GFAP) was studied in 160 cerebral tumors, mostly of neuro-epithelial nature. It was positive in astroglial tumors with an intensity proportional to the degree of cell differentiation. It was sometimes positive also in non-astroglial tumors, such as oligodendrogliomas and ependymomas, and this finding is discussed in relation to genesis and diagnostic value. In medulloblastomas, there were also positive cells, which could be reactive glia cells included in the tumors or subependymal cells. The demonstration of GFAP is very useful in gliosarcomas for identifying the glial component. It was sometimes positive in hemangioblastomas, and it is discussed in view of the nature of the stromal cells of this tumor.

Original languageEnglish
Pages (from-to)95-104
Number of pages10
JournalTumori
Volume69
Issue number2
Publication statusPublished - Apr 30 1983

ASJC Scopus subject areas

  • Cancer Research

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