Glial fibrillary acidic protein (GFAP) in rat brain tumors transplacentally induced by ethylnitrosourea (ENU)

A. Mauro, M. T. Glordana, A. Migheli, D. Schiffer

Research output: Contribution to journalArticlepeer-review

Abstract

The immunohistochemical distribution of glial fibrillary acidic protein (GFAP) in neoplastic lesions induced in the rat by ENU is reported. GFAP was present in hypertrophic reactive astrocytes, which were numerous in early neoplastic proliferations, in microtumors of the white matter, and in those collected at the periphery of large tumors. They were absent in cortical oligodendroglial foci and microtumors. No GFAP-positive cells were observed in hyperplasias of the white matter: astrocyte-like cells of large tumors were GFAP-negative. The significance of reactive astrocytes and the problem of the astrocytic component in transplacental ENU tumors are discussed.

Original languageEnglish
Pages (from-to)349-355
Number of pages7
JournalJournal of the Neurological Sciences
Volume61
Issue number3
DOIs
Publication statusPublished - 1983

Keywords

  • Astrocytes
  • Brain tumour
  • Ethylnitrosourea (ENU)
  • Glial fibrillary acidic protein (GFAP)
  • Rat

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

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