Abstract
The immunohistochemical distribution of glial fibrillary acidic protein (GFAP) in neoplastic lesions induced in the rat by ENU is reported. GFAP was present in hypertrophic reactive astrocytes, which were numerous in early neoplastic proliferations, in microtumors of the white matter, and in those collected at the periphery of large tumors. They were absent in cortical oligodendroglial foci and microtumors. No GFAP-positive cells were observed in hyperplasias of the white matter: astrocyte-like cells of large tumors were GFAP-negative. The significance of reactive astrocytes and the problem of the astrocytic component in transplacental ENU tumors are discussed.
Original language | English |
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Pages (from-to) | 349-355 |
Number of pages | 7 |
Journal | Journal of the Neurological Sciences |
Volume | 61 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1983 |
Keywords
- Astrocytes
- Brain tumour
- Ethylnitrosourea (ENU)
- Glial fibrillary acidic protein (GFAP)
- Rat
ASJC Scopus subject areas
- Ageing
- Clinical Neurology
- Surgery
- Neuroscience(all)
- Developmental Neuroscience
- Neurology