Glial Na+-dependent ion transporters in pathophysiological conditions

Francesca Boscia, Gulnaz Begum, Giuseppe Pignataro, Rossana Sirabella, Ornella Cuomo, Antonella Casamassa, Dandan Sun, Lucio Annunziato

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Sodium dynamics are essential for regulating functional processes in glial cells. Indeed, glial Na+ signaling influences and regulates important glial activities, and plays a role in neuron-glia interaction under physiological conditions or in response to injury of the central nervous system (CNS). Emerging studies indicate that Na+ pumps and Na+-dependent ion transporters in astrocytes, microglia, and oligodendrocytes regulate Na+ homeostasis and play a fundamental role in modulating glial activities in neurological diseases. In this review, we first briefly introduced the emerging roles of each glial cell type in the pathophysiology of cerebral ischemia, Alzheimer's disease, epilepsy, Parkinson's disease, Amyotrophic Lateral Sclerosis, and myelin diseases. Then, we discussed the current knowledge on the main roles played by the different glial Na+-dependent ion transporters, including Na+/K+ ATPase, Na+/Ca2+ exchangers, Na+/H+ exchangers, Na+-K+-Cl cotransporters, and Na+- HCO- 3 cotransporter in the pathophysiology of the diverse CNS diseases. We highlighted their contributions in cell survival, synaptic pathology, gliotransmission, pH homeostasis, and their role in glial activation, migration, gliosis, inflammation, and tissue repair processes. Therefore, this review summarizes the foundation work for targeting Na+-dependent ion transporters in glia as a novel strategy to control important glial activities associated with Na+ dynamics in different neurological disorders. GLIA 2016;64:1677–1697.

Original languageEnglish
Pages (from-to)1677-1697
Number of pages21
JournalGLIA
Volume64
Issue number10
DOIs
Publication statusPublished - Oct 1 2016

Fingerprint

Neuroglia
Ions
Homeostasis
Sodium-Potassium-Chloride Symporters
Sodium-Hydrogen Antiporter
Gliosis
Central Nervous System Diseases
Oligodendroglia
Amyotrophic Lateral Sclerosis
Microglia
Myelin Sheath
Nervous System Diseases
Brain Ischemia
Astrocytes
Parkinson Disease
Epilepsy
Cell Survival
Alzheimer Disease
Central Nervous System
Sodium

Keywords

  • astrocytes
  • microglia
  • Na-HCO cotransporter
  • Na-K-Cl cotransporter
  • Na/Ca exchanger
  • Na/H exchanger
  • Na/K ATPase
  • oligodendrocytes

ASJC Scopus subject areas

  • Neurology
  • Cellular and Molecular Neuroscience

Cite this

Boscia, F., Begum, G., Pignataro, G., Sirabella, R., Cuomo, O., Casamassa, A., ... Annunziato, L. (2016). Glial Na+-dependent ion transporters in pathophysiological conditions. GLIA, 64(10), 1677-1697. https://doi.org/10.1002/glia.23030

Glial Na+-dependent ion transporters in pathophysiological conditions. / Boscia, Francesca; Begum, Gulnaz; Pignataro, Giuseppe; Sirabella, Rossana; Cuomo, Ornella; Casamassa, Antonella; Sun, Dandan; Annunziato, Lucio.

In: GLIA, Vol. 64, No. 10, 01.10.2016, p. 1677-1697.

Research output: Contribution to journalReview article

Boscia, F, Begum, G, Pignataro, G, Sirabella, R, Cuomo, O, Casamassa, A, Sun, D & Annunziato, L 2016, 'Glial Na+-dependent ion transporters in pathophysiological conditions', GLIA, vol. 64, no. 10, pp. 1677-1697. https://doi.org/10.1002/glia.23030
Boscia F, Begum G, Pignataro G, Sirabella R, Cuomo O, Casamassa A et al. Glial Na+-dependent ion transporters in pathophysiological conditions. GLIA. 2016 Oct 1;64(10):1677-1697. https://doi.org/10.1002/glia.23030
Boscia, Francesca ; Begum, Gulnaz ; Pignataro, Giuseppe ; Sirabella, Rossana ; Cuomo, Ornella ; Casamassa, Antonella ; Sun, Dandan ; Annunziato, Lucio. / Glial Na+-dependent ion transporters in pathophysiological conditions. In: GLIA. 2016 ; Vol. 64, No. 10. pp. 1677-1697.
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