The rationale of this study was lo describe a group of 27 patients presenting with glioneuronal tumours (GNT) and epilepsy, and lo report the results of surgical treatment. From January 1992 lo December 2000, 27 patients were surgically treated for GNT The mean age was 27 years (range 6-6l years); 13 were females. 14 males. All patients undervent routine EEG and brain CT/MR scan. In all patients lesionectomy was performed. The mean interval between the onset of seizures and surgery was 10 years (range 2 months-35 years). The epilepsy was partial and pharmacoresistent in most of att cases. The site of the tumour was temporal in 18 cases (66,6%), extratemporal in 9 cases (33,3%). The ablation of the tumor was total in 22 patients (81,4%), sub-total m the remaining 5 patients (18,5%). Histopathological examination showed a ganglioglioma in 23 patients; a dysembrioplastic neuroepitelioma in 4 cases. Post-surgery complication occured in 6 cases (22,2%). Mean follow-up was 3,9 years (range 3 months-8years). 18 patients were seizure-free (Engel Class 1) (66,6%) (2 of them had withdrawn antiepileptic treatment), mean age al surgery: 13,3 years, 9 patients showed a decrement of seizure frequency (Engel Class II) (36.6%): mean age at surgery: 22.8 years. No relationship was observed between the outcome (Enget Class I or II) and site of turnouts, duration of epilepsy, seizure frequency. A better outcome (Class I versus Class II) was associated with surgery al a younger age (p<0.01).
|Translated title of the contribution||Glio-neuronal tumors and epilepsy: Results of 27 surgically treated cases|
|Number of pages||3|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 2001|
ASJC Scopus subject areas
- Clinical Neurology