Tumori Glio-neuronali

Esperienza su 36 casi

Translated title of the contribution: Glio-neuronal tumors

Marco Giulioni, Guido Rubboli, Federico Roncaroli, Alessandro Consales, Mino Zucchelli, Carlo Alberto Tassinari, Fabio Calbucci

Research output: Contribution to journalArticle

Abstract

The Glio-neuronal tumours (Gangliogliomas, Dysembrioplastic neuroepithelial tumours) are neoplasm composed by intimately admixed neuronal and glial component. They usually show themselves with clinical features of seizures and/or focal neurologic signs and symptoms. Since January 1992 to Decembr 2000, 36 patients were surgically treated for a glio-neuronal tumour. 27 cases (75%) presented epileptic seizures, 9 cases(25%) showed focal neurological symptoms. 18 were male, 18 female. The age ranged between 1 and 75 years with a mean age of 26.5 years. The tumour was located in the temporal lobe in 19 cases (52.7%), extratemporal in 17 cases (47.2%). About the group with seizures the mean presurgical duration of the epilepsy was 10 years. About the seizures type, these were partial complex in 15 cases (55,5%) partial whit secondary generalization in 8 cases (29.6%), partial complex with secondary generalization in 4 cases (14.8%). The frequency of the seizures was so distributed: sporadic in 2 cases, monthly in 4 case, over-montly in 11 cases, over-weekly in 4 cases, over daily in 6 cases. Among the 9 cases with focal symptoms, 4 patients suffered from hemiparesis, 1 from paresthesias, 1 from impairment of the visual field, 1 from torticollis, 1 from dizziness, 1 from motor and sensitibility symptoms. The removal of the tumour was total in 25 cases (70%), sub-total in 9 cases (25%), partial in 1 case (2,7%). The histological diagnosis showed gangliogliomas in 32 cases (23 with epilepsy, 9 with focal symptoms) Dysembrioplastic neuroepitelial tumors in 4 cases (everyone with epilepsy). Post-surgical complication appeared in 9 cases (25%): cerebellar hemorrhage in 2 cases, transitory aphasia in 1 case, transitory impairmen of oculomotor nerve in 1 case, transitory psychosis in 1 case, quadrantopsia in 1 case, aphasia-hemiparesis in 1 case, worsening of visual field in 1 case, worsening of hemiparesis in 1 case. The follow up ranged between 4 months and 8 years (mean 4,5 years) About the results of 27 patients with epilepsy, 18 (66,6%) were seizure-free (among these 2 without therapy, 16 with therapy), 9 were improved. Among the group of 9 cases with focal symptoms 5 were improved (55,5%), 2 were stationary (22,1%), 1 was worsened (11,1%), 1 died (11,1%). Histological features of anaplasia appeared in 3 cases: Re-operation was performed in 4 cases (3 gangliogliomas, 1 DNT) with recurrence or growth of residual tumour. Radiotherapy was performed in 4 cases.

Original languageItalian
Pages (from-to)305-310
Number of pages6
JournalRivista di Neurobiologia
Volume47
Issue number5
Publication statusPublished - 2001

Fingerprint

Ganglioglioma
Epilepsy
Seizures
Paresis
Neuroepithelial Neoplasms
2,6-dinitrotoluene
Aphasia
Neoplasms
Visual Fields
Anaplasia
Oculomotor Nerve
Torticollis
Paresthesia
Residual Neoplasm
Dizziness
Temporal Lobe
Neurologic Manifestations
Neuroglia
Psychotic Disorders
Radiotherapy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Giulioni, M., Rubboli, G., Roncaroli, F., Consales, A., Zucchelli, M., Tassinari, C. A., & Calbucci, F. (2001). Tumori Glio-neuronali: Esperienza su 36 casi. Rivista di Neurobiologia, 47(5), 305-310.

Tumori Glio-neuronali : Esperienza su 36 casi. / Giulioni, Marco; Rubboli, Guido; Roncaroli, Federico; Consales, Alessandro; Zucchelli, Mino; Tassinari, Carlo Alberto; Calbucci, Fabio.

In: Rivista di Neurobiologia, Vol. 47, No. 5, 2001, p. 305-310.

Research output: Contribution to journalArticle

Giulioni, M, Rubboli, G, Roncaroli, F, Consales, A, Zucchelli, M, Tassinari, CA & Calbucci, F 2001, 'Tumori Glio-neuronali: Esperienza su 36 casi', Rivista di Neurobiologia, vol. 47, no. 5, pp. 305-310.
Giulioni M, Rubboli G, Roncaroli F, Consales A, Zucchelli M, Tassinari CA et al. Tumori Glio-neuronali: Esperienza su 36 casi. Rivista di Neurobiologia. 2001;47(5):305-310.
Giulioni, Marco ; Rubboli, Guido ; Roncaroli, Federico ; Consales, Alessandro ; Zucchelli, Mino ; Tassinari, Carlo Alberto ; Calbucci, Fabio. / Tumori Glio-neuronali : Esperienza su 36 casi. In: Rivista di Neurobiologia. 2001 ; Vol. 47, No. 5. pp. 305-310.
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