Tumori Glio-neuronali: Esperienza su 36 casi

Translated title of the contribution: Glio-neuronal tumors

Marco Giulioni, Guido Rubboli, Federico Roncaroli, Alessandro Consales, Mino Zucchelli, Carlo Alberto Tassinari, Fabio Calbucci

Research output: Contribution to journalArticlepeer-review


The Glio-neuronal tumours (Gangliogliomas, Dysembrioplastic neuroepithelial tumours) are neoplasm composed by intimately admixed neuronal and glial component. They usually show themselves with clinical features of seizures and/or focal neurologic signs and symptoms. Since January 1992 to Decembr 2000, 36 patients were surgically treated for a glio-neuronal tumour. 27 cases (75%) presented epileptic seizures, 9 cases(25%) showed focal neurological symptoms. 18 were male, 18 female. The age ranged between 1 and 75 years with a mean age of 26.5 years. The tumour was located in the temporal lobe in 19 cases (52.7%), extratemporal in 17 cases (47.2%). About the group with seizures the mean presurgical duration of the epilepsy was 10 years. About the seizures type, these were partial complex in 15 cases (55,5%) partial whit secondary generalization in 8 cases (29.6%), partial complex with secondary generalization in 4 cases (14.8%). The frequency of the seizures was so distributed: sporadic in 2 cases, monthly in 4 case, over-montly in 11 cases, over-weekly in 4 cases, over daily in 6 cases. Among the 9 cases with focal symptoms, 4 patients suffered from hemiparesis, 1 from paresthesias, 1 from impairment of the visual field, 1 from torticollis, 1 from dizziness, 1 from motor and sensitibility symptoms. The removal of the tumour was total in 25 cases (70%), sub-total in 9 cases (25%), partial in 1 case (2,7%). The histological diagnosis showed gangliogliomas in 32 cases (23 with epilepsy, 9 with focal symptoms) Dysembrioplastic neuroepitelial tumors in 4 cases (everyone with epilepsy). Post-surgical complication appeared in 9 cases (25%): cerebellar hemorrhage in 2 cases, transitory aphasia in 1 case, transitory impairmen of oculomotor nerve in 1 case, transitory psychosis in 1 case, quadrantopsia in 1 case, aphasia-hemiparesis in 1 case, worsening of visual field in 1 case, worsening of hemiparesis in 1 case. The follow up ranged between 4 months and 8 years (mean 4,5 years) About the results of 27 patients with epilepsy, 18 (66,6%) were seizure-free (among these 2 without therapy, 16 with therapy), 9 were improved. Among the group of 9 cases with focal symptoms 5 were improved (55,5%), 2 were stationary (22,1%), 1 was worsened (11,1%), 1 died (11,1%). Histological features of anaplasia appeared in 3 cases: Re-operation was performed in 4 cases (3 gangliogliomas, 1 DNT) with recurrence or growth of residual tumour. Radiotherapy was performed in 4 cases.

Translated title of the contributionGlio-neuronal tumors
Original languageItalian
Pages (from-to)305-310
Number of pages6
JournalRivista di Neurobiologia
Issue number5
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Neuroscience(all)


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