Glioblastoma in kidney transplant recipients. Report of five cases

Maurizio Salvati, Alessandro Frati, Emanuela Caroli, Natale Russo, Filippo M. Polli, Maurizio Domenicucci, Roberto Delfini

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Abstract

Five patients who developed an intracranial glioblastoma after a kidney transplant are described. All patients underwent surgical removal of the lesion and eventually radiation therapy, but none of them is still alive at follow-up. The possibility of tumours occurring in transplant recipients is a recognised entity and several series have been reported. Nevertheless, little consideration has been paid to post-transplant gliomas and a precise evaluation of this risk is still lacking. Several hypotheses have been proposed to explain a possible link. One possible factor may be the immunosuppressive state of recipients as a result of post-transplant administration of immunosuppressive drugs, as it is known that gliomas have an higher incidence in HIV-infected patients. However, it is not yet clear whether immunosuppressive drugs function as a direct transforming factor.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalJournal of Neuro-Oncology
Volume63
Issue number1
DOIs
Publication statusPublished - 2003

Keywords

  • Gliomas
  • Post-transplant
  • Transplant
  • Tumours

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neurology

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