Glioblastoma in multiple sclerosis: A case report

Giovanni Frisullo, Agata Katia Patanella, Viviana Nociti, Alessandro Cianfoni, Raffaele Iorio, Assunta Bianco, Alessandro Marti, Pietro Attilio Tonali, Anna Paola Batocchi

Research output: Contribution to journalArticle

Abstract

Cerebral tumor and multiple sclerosis (MS) relapses can show overlapping clinical and magnetic resonance imaging features. In a previous study we observed in relapsing MS patients increased T-bet, pSTAT1, and pSTAT3 expressions in circulating mononuclear cells. During the data analysis we observed that T-bet, pSTAT1, and pSTAT3 expression was not increased in circulating mononuclear cells from a relapsing-remitting (RR)MS patient with recent onset of new neurological signs due to glioblastoma multiforme. In conclusion, our patient represents an exemplary case which suggests that T-bet, pSTAT1, and pSTAT3 expression in peripheral blood mononuclear cells (PBMCs) might be useful to differentiate MS relapses from other noninflammatory diseases.

Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalJournal of Neuro-Oncology
Volume94
Issue number1
DOIs
Publication statusPublished - 2009

Keywords

  • Differential diagnosis
  • Glioblastoma multiforme
  • Multiple sclerosis
  • Transcription factors

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neurology

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  • Cite this

    Frisullo, G., Patanella, A. K., Nociti, V., Cianfoni, A., Iorio, R., Bianco, A., Marti, A., Tonali, P. A., & Batocchi, A. P. (2009). Glioblastoma in multiple sclerosis: A case report. Journal of Neuro-Oncology, 94(1), 141-144. https://doi.org/10.1007/s11060-009-9804-9