GLIS3 and Thyroid: A Pleiotropic Candidate Gene for Congenital Hypothyroidism

Giuditta Rurale, Luca Persani, Federica Marelli

Research output: Contribution to journalArticle

Abstract

Variations in the transcription factor Gli-similar 3 (GLIS3) gene have been associated to variable congenital endocrine defects, including both morphogenetic and functional thyroid alterations. Evidence from Glis3 knockout mice indicates a relevant role for GLIS3 in thyroid hormone biosynthesis and postnatal thyroid gland growth, with a mechanism of action downstream of the TSH/TSHR interaction. However, the pathophysiological role of this transcription factor during the embryonic thyroid development remains unexplored. In this manuscript, we will provide an overview of the current knowledge on GLIS3 function during development. As a perspective, we will present preliminary evidence in the zebrafish model in support of a potential role for this pleiotropic transcription factor in the early stages of thyroid gland development.

Original languageEnglish
Pages (from-to)730
JournalFrontiers in Endocrinology
Volume9
DOIs
Publication statusPublished - 2018

Fingerprint Dive into the research topics of 'GLIS3 and Thyroid: A Pleiotropic Candidate Gene for Congenital Hypothyroidism'. Together they form a unique fingerprint.

  • Cite this