Global functional coupling of resting EEG rhythms is abnormal in mild cognitive impairment and Alzheimer's disease: A multicenter EEG study

Claudio Babiloni, Giovanni Frisoni, Fabrizio Vecchio, Roberta Lizio, Michela Pievani, Cristina Geroldi, Claudia Fracassi, Fabrizio Vernieri, Francesca Ursini, Guido Rodriguez, Flavio Nobili, Serenella Salinari, Sven van Dijkman, Raffaele Ferri, Paolo M. Rossini

Research output: Contribution to journalArticlepeer-review

Abstract

Alzheimer's disease (AD) is typically associated with an impairment of brain networks and global cognitive function in aging. In this vein, the present study tested the hypothesis that the functional coupling of resting cortical electroencephalographic (EEG) rhythms is progressively abnormal in amnesic mild cognitive impairment (MCI) and AD subjects. Eyes-closed resting EEG data were recorded (10-20 system) in 33 mild AD, 52 amnesic MCI, and 47 normal elderly subjects (Nold). EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha1 (8-10 Hz), alpha2 (10-13 Hz), beta1 (13-20 Hz), beta2 (20-30 Hz), and gamma (30-40 Hz). The global functional coupling of the EEG rhythms was indexed by means of spectral coherence for all combinations of electrode pairs (i.e., total coherence). The main results showed that the total coherence of delta rhythms was higher in the AD than the MCI group. It was also higher in the MCI than the Nold group. Furthermore, the delta total coherence was negatively correlated with global cognition (Mini Mental State Examination score) across the Nold, MCI, and AD subjects. Finally, the alpha1 total coherence was lower in the AD group than in the MCI and Nold groups. These results suggest that in the AD process an impairment of brain networks and global cognition is associated with a frequency-specific modulation of the global functional coupling of resting EEG rhythms.

Original languageEnglish
Pages (from-to)224-234
Number of pages11
JournalJournal of Psychophysiology
Volume23
Issue number4
DOIs
Publication statusPublished - 2009

Keywords

  • Alzheimer's disease (AD)
  • EEG rhythms
  • Electroencephalography (EEG)
  • Mild cognitive impairment (MCI)
  • Mini mental state evaluation (MMSE)
  • Spectral coherence
  • Total coherence

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Physiology

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