Global real-world evidence of sofosbuvir/velpatasvir as simple, effective HCV treatment: Analysis of 5552 patients from 12 cohorts

Alessandra Mangia, Scott Milligan, Mandana Khalili, Stefano Fagiuoli, Stephen D. Shafran, Fabrice Carrat, Denis Ouzan, George Papatheodoridis, Alnoor Ramji, Sergio M. Borgia, Heiner Wedemeyer, Ruggero Losappio, Francisco Pérez-Hernandez, Nicole Wick, Robert S. Brown, Pietro Lampertico, Karen Doucette, Ioanna Ntalla, Heribert Ramroth, Michael MertensKim Vanstraelen, Juan Turnes

Research output: Contribution to journalArticle

Abstract

Background and aims: Achieving sustained virological response (SVR; cure) in hepatitis C patients using a simple regimen is key to making elimination by 2030 possible. In the largest real-world analysis to date, the effectiveness of pangenotypic, panfibrotic, single-tablet, sofosbuvir/velpatasvir (SOF/VEL) once-daily for 12 weeks was assessed in 12 clinical real-world cohorts from various geographical areas, settings and treatment practices. Factors affecting risk of not achieving SVR were assessed. Methods: Adults treated with SOF/VEL 400/100 mg, without ribavirin, were included. All HCV patients reaching Week 12 or 24 post-treatment were assessed for SVR12/24. Factors associated with not achieving SVR12/24 for virological reasons were evaluated using logistic regression analysis. Results: Overall, 5552 patients were included: 13.3% treatment-experienced; 20.7% compensated cirrhotic; 30.2% genotype 1; 29.5% genotype 2; 32.9% genotype 3; 4.7% genotype 4; 3.7% HIV coinfection; 13.4% current/former intravenous drug use. Of the 5196 patients evaluated for effectiveness, 98.9% achieved SVR12/24. High SVR12/24 rates occurred in all genotypes including genotype 3 (98.3%; 1649/1677) and in those with compensated cirrhosis (97.9; 1055/1078). Only 55 patients did not achieve SVR12/24 due to a virological reason; the only factor statistically significantly associated with an increased risk of not achieving SVR12/24 was compensated cirrhosis (P =.002). Overall, 6% (332/5552) of patients did not achieve SVR12/24 for non-virological reasons (67% lost to follow-up; 26.5% early treatment discontinuation). Conclusions: In this large cohort, representative of clinical practice, a simple 12-week regimen of SOF/VEL without ribavirin resulted in high SVR12/24 rates in diverse patient populations, even among those with compensated cirrhosis.

Original languageEnglish
JournalLiver International
DOIs
Publication statusAccepted/In press - Jan 1 2020

Keywords

  • HCV elimination
  • Hepatitis C
  • heterogenous
  • real-world
  • sofosbuvir/velpatasvir
  • sustained virological response

ASJC Scopus subject areas

  • Hepatology

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    Mangia, A., Milligan, S., Khalili, M., Fagiuoli, S., Shafran, S. D., Carrat, F., Ouzan, D., Papatheodoridis, G., Ramji, A., Borgia, S. M., Wedemeyer, H., Losappio, R., Pérez-Hernandez, F., Wick, N., Brown, R. S., Lampertico, P., Doucette, K., Ntalla, I., Ramroth, H., ... Turnes, J. (Accepted/In press). Global real-world evidence of sofosbuvir/velpatasvir as simple, effective HCV treatment: Analysis of 5552 patients from 12 cohorts. Liver International. https://doi.org/10.1111/liv.14537