Global skeletal uptake of 99mTc-methylene diphosphonate (GSU) in patients affected by endocrine diseases: Comparison with biochemical markers of bone turnover

A. Scillitani, F. Dicembrino, I. Chiodini, S. Minisola, S. Fusilli, A. Di Giorgio, M. Garrubba, L. D'Aloiso, V. Frusciante, M. Torlontano, S. Modoni, V. Trischitta, V. Carnevale

Research output: Contribution to journalArticlepeer-review

Abstract

This study aimed to clinically validate the global skeletal uptake (GSU) of 99mTc-methylene diphosphonate (99mTc-MDP), and to compare it with a marker of bone formation (i.e. serum osteocalcin or OC) and an index of bone resorption (i.e. urinary deoxypyridinoline or U-DPD) in different endocrine disorders affecting the skeleton. We studied 29 female patients with thyrotoxicosis (TT), 27 with primary hyperparathyroidism (PHPT), 16 with acromegaly (AC), 15 with Cushing's syndrome (CS), and altogether 110 healthy women matched for age, BMI and menstrual status. In all subjects total body digital scan images (TBDS) were acquired at 5 min and at 4 h after the administration of 99mTc-MDP; the whole body retention (WBR) of the tracer was measured by counting two identical sets of rectangular ROIs, and GSU was subsequently calculated by drawing an irregular ROI on 4 h TBDS images. Serum OC was assessed by IRMA and urinary DPD by fluorometric detection after reverse phase high pressure chromatography. In TT patients GSU (40.0 ± 5.1 vs 36.5 ± 4.8%), OC (19.1 ± 11.8 vs 7.1 ± 2.9 μg/l) and U-DPD (62.4 ± 42.7 vs 19.5 ± 5.3 pmol/pmol) were significantly (p

Original languageEnglish
Pages (from-to)829-834
Number of pages6
JournalOsteoporosis International
Volume13
Issue number10
DOIs
Publication statusPublished - Oct 1 2002

Keywords

  • Bone turnover
  • Deoxypyridinoline
  • Endocrine diseases
  • Global Skeletal Uptake
  • Osteocalcin Tc-MDP

ASJC Scopus subject areas

  • Medicine(all)

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