TY - JOUR
T1 - Global skeletal uptake of 99mTc-methylene diphosphonate (GSU) in patients affected by endocrine diseases
T2 - Comparison with biochemical markers of bone turnover
AU - Scillitani, A.
AU - Dicembrino, F.
AU - Chiodini, I.
AU - Minisola, S.
AU - Fusilli, S.
AU - Di Giorgio, A.
AU - Garrubba, M.
AU - D'Aloiso, L.
AU - Frusciante, V.
AU - Torlontano, M.
AU - Modoni, S.
AU - Trischitta, V.
AU - Carnevale, V.
PY - 2002/10/1
Y1 - 2002/10/1
N2 - This study aimed to clinically validate the global skeletal uptake (GSU) of 99mTc-methylene diphosphonate (99mTc-MDP), and to compare it with a marker of bone formation (i.e. serum osteocalcin or OC) and an index of bone resorption (i.e. urinary deoxypyridinoline or U-DPD) in different endocrine disorders affecting the skeleton. We studied 29 female patients with thyrotoxicosis (TT), 27 with primary hyperparathyroidism (PHPT), 16 with acromegaly (AC), 15 with Cushing's syndrome (CS), and altogether 110 healthy women matched for age, BMI and menstrual status. In all subjects total body digital scan images (TBDS) were acquired at 5 min and at 4 h after the administration of 99mTc-MDP; the whole body retention (WBR) of the tracer was measured by counting two identical sets of rectangular ROIs, and GSU was subsequently calculated by drawing an irregular ROI on 4 h TBDS images. Serum OC was assessed by IRMA and urinary DPD by fluorometric detection after reverse phase high pressure chromatography. In TT patients GSU (40.0 ± 5.1 vs 36.5 ± 4.8%), OC (19.1 ± 11.8 vs 7.1 ± 2.9 μg/l) and U-DPD (62.4 ± 42.7 vs 19.5 ± 5.3 pmol/pmol) were significantly (p
AB - This study aimed to clinically validate the global skeletal uptake (GSU) of 99mTc-methylene diphosphonate (99mTc-MDP), and to compare it with a marker of bone formation (i.e. serum osteocalcin or OC) and an index of bone resorption (i.e. urinary deoxypyridinoline or U-DPD) in different endocrine disorders affecting the skeleton. We studied 29 female patients with thyrotoxicosis (TT), 27 with primary hyperparathyroidism (PHPT), 16 with acromegaly (AC), 15 with Cushing's syndrome (CS), and altogether 110 healthy women matched for age, BMI and menstrual status. In all subjects total body digital scan images (TBDS) were acquired at 5 min and at 4 h after the administration of 99mTc-MDP; the whole body retention (WBR) of the tracer was measured by counting two identical sets of rectangular ROIs, and GSU was subsequently calculated by drawing an irregular ROI on 4 h TBDS images. Serum OC was assessed by IRMA and urinary DPD by fluorometric detection after reverse phase high pressure chromatography. In TT patients GSU (40.0 ± 5.1 vs 36.5 ± 4.8%), OC (19.1 ± 11.8 vs 7.1 ± 2.9 μg/l) and U-DPD (62.4 ± 42.7 vs 19.5 ± 5.3 pmol/pmol) were significantly (p
KW - Bone turnover
KW - Deoxypyridinoline
KW - Endocrine diseases
KW - Global Skeletal Uptake
KW - Osteocalcin Tc-MDP
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U2 - 10.1007/s001980200115
DO - 10.1007/s001980200115
M3 - Article
C2 - 12378373
AN - SCOPUS:0036820573
VL - 13
SP - 829
EP - 834
JO - Osteoporosis International
JF - Osteoporosis International
SN - 0937-941X
IS - 10
ER -