Globally attractive oscillations in open monosubstrate allosteric enzyme reactions

Alberto d'Onofrio

Research output: Contribution to journalArticlepeer-review


Here we study the dynamical properties of glycolytic and other similar biochemical oscillation-generating processes by means of the analysis of a model proposed by Golbdeter and Lefever (Bioph J 13:1302-1315, 1972) in a reduced form proposed by Keener and Sneyd (Mathematical physiology, chap 1, Springer Verlag, Berlin, 2009). After showing that the orbits of the system are bounded, we give some conditions for the existence of oscillations and for the global arrest of them. Then, after deriving an equivalent Lienard-Newton's equation we assess uniqueness and the global stability of the arising limit cycle. Finally, we shortly investigate the possibility of breaking of the spatial symmetry. Some biological remarks end the work.

Original languageEnglish
Pages (from-to)531-545
Number of pages15
JournalJournal of Mathematical Chemistry
Issue number2
Publication statusPublished - 2011


  • Global stability
  • Glycolysis
  • Lienard's equation
  • Limit cycles
  • Turing's bifurcations

ASJC Scopus subject areas

  • Chemistry(all)
  • Applied Mathematics


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