Globin RNA sequences in human leukaemic peripheral blood

A. M. Gianni, R. Dalla Favera, E. Polli, I. Merisio, B. Giglioni, P. Comi, S. Ottolenghi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Evidence for the involvement of more than one cell line and even interconversion of different forms of human leukaemia suggests that the neoplastic transformation occurs in a common stem cell. Although erythroid leukaemias are very rare in humans, disturbances in haemopoiesis or haemoglobin synthesis are common in leukaemia, suggesting the possible involvement of erythroid precursors. We show here, by the use of sensitive cDNA (complementary DNA)-RNA hybridisation, that in a substantial number of human leukemias globin RNA sequences can be demonstrated in nuclear RNA prepared from highly purified leukaemic cell populations.

Original languageEnglish
Pages (from-to)610-612
Number of pages3
JournalNature
Volume274
Issue number5671
DOIs
Publication statusPublished - 1978

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Globins
Leukemia
Nuclear RNA
Complementary RNA
Hemoglobins
Stem Cells
Complementary DNA
Cell Line
Population

ASJC Scopus subject areas

  • General

Cite this

Gianni, A. M., Dalla Favera, R., Polli, E., Merisio, I., Giglioni, B., Comi, P., & Ottolenghi, S. (1978). Globin RNA sequences in human leukaemic peripheral blood. Nature, 274(5671), 610-612. https://doi.org/10.1038/274610a0

Globin RNA sequences in human leukaemic peripheral blood. / Gianni, A. M.; Dalla Favera, R.; Polli, E.; Merisio, I.; Giglioni, B.; Comi, P.; Ottolenghi, S.

In: Nature, Vol. 274, No. 5671, 1978, p. 610-612.

Research output: Contribution to journalArticle

Gianni, AM, Dalla Favera, R, Polli, E, Merisio, I, Giglioni, B, Comi, P & Ottolenghi, S 1978, 'Globin RNA sequences in human leukaemic peripheral blood', Nature, vol. 274, no. 5671, pp. 610-612. https://doi.org/10.1038/274610a0
Gianni AM, Dalla Favera R, Polli E, Merisio I, Giglioni B, Comi P et al. Globin RNA sequences in human leukaemic peripheral blood. Nature. 1978;274(5671):610-612. https://doi.org/10.1038/274610a0
Gianni, A. M. ; Dalla Favera, R. ; Polli, E. ; Merisio, I. ; Giglioni, B. ; Comi, P. ; Ottolenghi, S. / Globin RNA sequences in human leukaemic peripheral blood. In: Nature. 1978 ; Vol. 274, No. 5671. pp. 610-612.
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