Glomerular diseases and cancer: evaluation of underlying malignancy

A. Pani, Camillo Porta, Laura Cosmai, Patrizia Melis, Matteo Floris, D. Piras, Maurizio Gallieni, Mitchell Rosner, Claudio Ponticelli

Research output: Contribution to journalArticle

Abstract

Onconephrology is an emerging medical subspecialty focused on the numerous interconnections between cancer and kidney diseases. Patient with malignancies commonly experience kidney problems including acute kidney injury, tumor lysis syndrome, fluid and electrolyte disorders and chronic kidney disease, often as a consequence of the anti-cancer treatment. Conversely, a number of glomerulopathies, tubulopathies and vascular renal diseases can early signal the presence of an underlying cancer. Furthermore, the administration of immunosuppressive drugs, especially cytotoxic drugs and calcineurin inhibitors, may strongly impair the immune response increasing the risk of cancer. The objective of this review article is to: (i) discuss paraneoplastic glomerular disease, (ii) review cancer as an adverse effect of immunosuppressive agents used to treat glomerulopathies, and (iii) in the absence of international approved guidelines, propose a screening program based on expert opinion aimed at guiding nephrologists to early detect malignancies during their clinical practice.

Original languageEnglish
Pages (from-to)143-152
Number of pages10
JournalJournal of Nephrology
Volume29
Issue number2
DOIs
Publication statusPublished - Apr 1 2016

Fingerprint

Neoplasms
Immunosuppressive Agents
Tumor Lysis Syndrome
Kidney
Kidney Neoplasms
Expert Testimony
Kidney Diseases
Chronic Renal Insufficiency
Vascular Diseases
Acute Kidney Injury
Pharmaceutical Preparations
Electrolytes
Guidelines
Therapeutics
Calcineurin Inhibitors
Nephrologists

Keywords

  • Cancer
  • Glomerular diseases
  • Immunosuppressive therapy
  • Membranous nephropathy
  • Nephrotic syndrome
  • Onconephrology

ASJC Scopus subject areas

  • Nephrology

Cite this

Pani, A., Porta, C., Cosmai, L., Melis, P., Floris, M., Piras, D., ... Ponticelli, C. (2016). Glomerular diseases and cancer: evaluation of underlying malignancy. Journal of Nephrology, 29(2), 143-152. https://doi.org/10.1007/s40620-015-0234-9

Glomerular diseases and cancer : evaluation of underlying malignancy. / Pani, A.; Porta, Camillo; Cosmai, Laura; Melis, Patrizia; Floris, Matteo; Piras, D.; Gallieni, Maurizio; Rosner, Mitchell; Ponticelli, Claudio.

In: Journal of Nephrology, Vol. 29, No. 2, 01.04.2016, p. 143-152.

Research output: Contribution to journalArticle

Pani, A, Porta, C, Cosmai, L, Melis, P, Floris, M, Piras, D, Gallieni, M, Rosner, M & Ponticelli, C 2016, 'Glomerular diseases and cancer: evaluation of underlying malignancy', Journal of Nephrology, vol. 29, no. 2, pp. 143-152. https://doi.org/10.1007/s40620-015-0234-9
Pani A, Porta C, Cosmai L, Melis P, Floris M, Piras D et al. Glomerular diseases and cancer: evaluation of underlying malignancy. Journal of Nephrology. 2016 Apr 1;29(2):143-152. https://doi.org/10.1007/s40620-015-0234-9
Pani, A. ; Porta, Camillo ; Cosmai, Laura ; Melis, Patrizia ; Floris, Matteo ; Piras, D. ; Gallieni, Maurizio ; Rosner, Mitchell ; Ponticelli, Claudio. / Glomerular diseases and cancer : evaluation of underlying malignancy. In: Journal of Nephrology. 2016 ; Vol. 29, No. 2. pp. 143-152.
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