Glossopexy as an alternative to aortopexy in infants with repaired esophageal atresia and upper airway obstruction

Francesco Cozzi, Francesco Morini, Alessandra Casati, Daniela Camanni, Augusto Zani, Denis A. Cozzi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background/Purpose: Clinical manifestations of airway obstruction in infants with repaired esophageal atresia or tracheoesophageal fistula (EA/TEF) are attributed conventionally to tracheomalacia. In the current study, the authors tested the hypothesis that a retrodisplacement of the tongue (glossoptosis), by causing a functional upper airway obstruction (obstructive apnea/hypopnea), may play a role in the pathogenesis of the respiratory problems. Methods: The records of 5 infants with repaired EA/TEF and respiratory symptoms treated by glossopexy, which serves to anchor the tongue forward, were reviewed. Prompt improvement after glossopexy in clinical manifestations, in blood gas exchange, and in weight velocity was used to establish a primary cause-effect relationship between glossoptosis and respiratory problems. Results: Before glossopexy, all infants presented with severe respiratory distress. Three infants had life-threatening events requiring recurrent or chronic airway intubation. Four infants had severe tracheomalacia, diagnosed at bronchoscopy. All infants presented obstructive apnea/hypopnea with desaturation. Body weight was below the third percentile in all infants. After glossopexy, 3 presented a marked clinical improvement associated with significant increase in mean oxygen saturation (88% ± 0.4 SE v95% ± 0.3 SE; P <.001). In another infant, glossopexy allowed permanent decannulation but did not relieve the problem during crying or excitement when obstructive hypopnea with desaturation required supplemental oxygen. After glossopexy and despite subsequent aortopexy, the last infant could not be extubated and died later of mycotic sepsis. Autopsy results showed a vascular ring. In the 4 surviving infants, glossopexy was followed promptly by significant catch-up growth and subsequent normal growth velocity (P = .03). Conclusions: Present findings support the concept that, in some infants with EA/TEF, respiratory problems are mainly caused by recurrent obstructive apnea/hypopnea, which may be treated successfully by lip-tongue adhesion procedures. Severe airway obstruction, not relieved by glossopexy, requires aortopexy to reduce the respiratory load imposed by tracheomalacia.

Original languageEnglish
Pages (from-to)202-206
Number of pages5
JournalJournal of Pediatric Surgery
Volume37
Issue number2
DOIs
Publication statusPublished - 2002

Fingerprint

Esophageal Atresia
Apnea
Tracheomalacia
Tongue
Oxygen
Crying
Bronchoscopy
Growth
Lip
Intubation
Blood Vessels
Autopsy
Sepsis
Gases
Body Weight

Keywords

  • Apparent life-threatening event (ALTE)
  • Laryngomalacia
  • Obstructive sleep apnea
  • Pierre Robin syndrome
  • Stridor
  • Tracheomalacia

ASJC Scopus subject areas

  • Surgery

Cite this

Glossopexy as an alternative to aortopexy in infants with repaired esophageal atresia and upper airway obstruction. / Cozzi, Francesco; Morini, Francesco; Casati, Alessandra; Camanni, Daniela; Zani, Augusto; Cozzi, Denis A.

In: Journal of Pediatric Surgery, Vol. 37, No. 2, 2002, p. 202-206.

Research output: Contribution to journalArticle

Cozzi, Francesco ; Morini, Francesco ; Casati, Alessandra ; Camanni, Daniela ; Zani, Augusto ; Cozzi, Denis A. / Glossopexy as an alternative to aortopexy in infants with repaired esophageal atresia and upper airway obstruction. In: Journal of Pediatric Surgery. 2002 ; Vol. 37, No. 2. pp. 202-206.
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AU - Camanni, Daniela

AU - Zani, Augusto

AU - Cozzi, Denis A.

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