Glubran 2®: A new acrylic glue for neuroradiological endovascular use: A complementary histological study

Marco Leonardi, P. Cenni, L. Simonetti, A. Bozzao, A. Romano, M. Bonamini, L. M. Fantozzi, G. Fini

Research output: Contribution to journalArticle

Abstract

Two Landrace Large White swine underwent angiography by the femoral route. In both cases, the superior left renal artery was embolized by injection of 2 ml of Glubran 2®, diluted with Lipiodol 1:1 thereby excluding the superior left kidney poles from blood flow. During the follow-up period, neither pig presented any clinical symptom correlated to the embolization procedure. Case 1 was sacrificed after 30 days and case 2 after 60 days. Macroscopic and microscopic analysis was performed in both animals. Long-term follow-up of the two cases after endovascular injection of Glubran 2® showed that the embolization procedure was well-tolerated by the swine in terms of clinical symptoms and histological findings. Arterial occlusion was stable and a reasonable quantity of scar tissue appeared between 30 and 60 days, surrounding the ischaemic tissue. This follow-up experimental study offers further evidence that Glubran 2® is a safe embolizing material for human use as far as its chemical activity is concerned.

Original languageEnglish
Pages (from-to)249-254
Number of pages6
JournalInterventional Neuroradiology
Volume9
Issue number3
Publication statusPublished - Sep 2003

Keywords

  • Acrylic glue
  • Embolization
  • Experimental neuroradiology

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Radiological and Ultrasound Technology

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    Leonardi, M., Cenni, P., Simonetti, L., Bozzao, A., Romano, A., Bonamini, M., Fantozzi, L. M., & Fini, G. (2003). Glubran 2®: A new acrylic glue for neuroradiological endovascular use: A complementary histological study. Interventional Neuroradiology, 9(3), 249-254.