Glucagon-, glicentin-, and pancreatic polypeptide-like immunoreactivities in rectal carcinoids and related colorectal cells

R. Fiocca, C. Capella, R. Buffa, R. Fontana, E. Solcia, E. Hage, R. E. Chance, A. J. Moody

Research output: Contribution to journalArticle

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Abstract

Three nonargentaffin rectal carcinoids have been investigated immunohistochemically. In one case most tumor cells reacted with antiglucagon sera as well as with antiglicentin, antibovine pancreatic polypeptide (BPP), and antihuman pancreatic polypeptide (HPP) sera; they were identified ultrastructurally as L cells. Another case showed glucagon-, glicentin-, and BPP-immunoreactive cells but lacked HPP immunoreactivity. In the third case glucagon- and glicentin-immunoreactive cells were well represented, while PP immunoreactivities were scarce. Parallel imvestigations of human rectal and sigmoid mucosa showed numerous cells reacting with glucagon, glicentin, and BPP antisera, most of which lacked HPP immunoreactivity. Cells reacting with glucagon and glicentin antisera, while lacking PP immunoreactivities, were also found. Thus, both tumor and nontumor cells produce glucagonlike immunoreactive (GLI) peptides - one of which may be glicentin or a related molecule - as well as PP-related sequences, although differing histochemically and ultrastructurally from glucagon or PP cells of the human pancreas. It is concluded that nonargentaffin rectal carcinoids are histogenetically linked to nonargentaffin endocrine cells of the human rectum.

Original languageEnglish
Pages (from-to)81-92
Number of pages12
JournalAmerican Journal of Pathology
Volume100
Issue number1
Publication statusPublished - 1980

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Glicentin
Pancreatic Polypeptide
Carcinoid Tumor
Glucagon
Immune Sera
Endocrine Cells
Sigmoid Colon
Serum
Rectum
Pancreas
Neoplasms
Mucous Membrane

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Glucagon-, glicentin-, and pancreatic polypeptide-like immunoreactivities in rectal carcinoids and related colorectal cells. / Fiocca, R.; Capella, C.; Buffa, R.; Fontana, R.; Solcia, E.; Hage, E.; Chance, R. E.; Moody, A. J.

In: American Journal of Pathology, Vol. 100, No. 1, 1980, p. 81-92.

Research output: Contribution to journalArticle

Fiocca, R. ; Capella, C. ; Buffa, R. ; Fontana, R. ; Solcia, E. ; Hage, E. ; Chance, R. E. ; Moody, A. J. / Glucagon-, glicentin-, and pancreatic polypeptide-like immunoreactivities in rectal carcinoids and related colorectal cells. In: American Journal of Pathology. 1980 ; Vol. 100, No. 1. pp. 81-92.
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AU - Capella, C.

AU - Buffa, R.

AU - Fontana, R.

AU - Solcia, E.

AU - Hage, E.

AU - Chance, R. E.

AU - Moody, A. J.

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AB - Three nonargentaffin rectal carcinoids have been investigated immunohistochemically. In one case most tumor cells reacted with antiglucagon sera as well as with antiglicentin, antibovine pancreatic polypeptide (BPP), and antihuman pancreatic polypeptide (HPP) sera; they were identified ultrastructurally as L cells. Another case showed glucagon-, glicentin-, and BPP-immunoreactive cells but lacked HPP immunoreactivity. In the third case glucagon- and glicentin-immunoreactive cells were well represented, while PP immunoreactivities were scarce. Parallel imvestigations of human rectal and sigmoid mucosa showed numerous cells reacting with glucagon, glicentin, and BPP antisera, most of which lacked HPP immunoreactivity. Cells reacting with glucagon and glicentin antisera, while lacking PP immunoreactivities, were also found. Thus, both tumor and nontumor cells produce glucagonlike immunoreactive (GLI) peptides - one of which may be glicentin or a related molecule - as well as PP-related sequences, although differing histochemically and ultrastructurally from glucagon or PP cells of the human pancreas. It is concluded that nonargentaffin rectal carcinoids are histogenetically linked to nonargentaffin endocrine cells of the human rectum.

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