Several workers have pointed out that glucose and aminoacids (e.g. ARG) may stimulate IRG and IRI release through different mechanisms and that their action may be affected by several drugs in different ways. In the rat pancreas in vitro 5HT, in concentrations believed to be physiologic, inhibits IRG and IRI response to glucose alone, while metergoline, a selective 5HT-antagonist, stimulates IRG and IRI release; similarly, HA, in physiologic concentrations (2 mM and 4 mM), stimulates IRG and inhibits IRI release, and the opposite effect is exerted by HA-antagonists. In this paper we report the effects of 5HT and HA, at the above concentrations, and of their precursors, on the IRG and IRI response to ARG, the aminoacid being used at concentrations (2 mM) similar to that found in plasma during the postabsorptive state.
|Number of pages||2|
|Journal||Hormone and Metabolic Research|
|Publication status||Published - 1980|
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