Glucocorticoid interactions with the dorsal striatal endocannabinoid system in regulating inhibitory avoidance memory

Cristina Siller-Pérez, Antonio Fuentes-Ibañez, Erika L. Sotelo-Barrera, Norma Serafín, Roberto A. Prado-Alcalá, Patrizia Campolongo, Benno Roozendaal, Gina L. Quirarte

Research output: Contribution to journalArticle

Abstract

The endocannabinoid (eCB) system is highly stress sensitive and known to modulate memory formation of emotionally arousing experiences across different corticolimbic structures. eCB signaling within these circuits is also essentially involved in regulating non-genomically mediated glucocorticoid hormone effects on memory. It has long been thought that the dorsal striatum, which plays a major role in procedural memory and habit formation, is considerably less impacted by stressful experiences; however, recent findings indicate that stress and glucocorticoids also affect striatal-dependent memory processes. Yet, to what extent eCB signaling within the dorsal striatum may mediate such glucocorticoid effects on memory consolidation is currently unknown. Here we show, in male Wistar rats, that the cannabinoid agonist WIN55,212-2 administered into the dorsal striatum immediately after an inhibitory avoidance training experience dose-dependently enhanced 48-h retention performance. Conversely, the cannabinoid type 1 receptor (CB1R) antagonist AM251 impaired retention when administered into the dorsal striatum after inhibitory avoidance training. Most importantly, antagonism of striatal CB1R activity with AM251 completely abolished the effect of corticosterone or of the membrane-impermeable ligand corticosterone:BSA administered posttraining into the dorsal striatum or injected systemically on enhancement of inhibitory avoidance memory. Further, suppression of glucocorticoid signaling by systemic injection of the corticosterone-synthesis inhibitor metyrapone also impaired the memory-enhancing effect of intra-striatal WIN55, 212-2 administration. These findings indicate that the eCB system, in close interaction with glucocorticoid signaling, is involved in modulating plasticity changes underlying memory consolidation not only in corticolimbic structures but also within the dorsal striatum.

Original languageEnglish
Pages (from-to)97-103
Number of pages7
JournalPsychoneuroendocrinology
Volume99
DOIs
Publication statusE-pub ahead of print - 2018

Fingerprint

Corpus Striatum
Endocannabinoids
Glucocorticoids
Corticosterone
Cannabinoid Receptor Antagonists
Cannabinoid Receptor Agonists
Metyrapone
Cannabinoid Receptors
Habits
Wistar Rats
Hormones
Ligands
Injections
Membranes

Keywords

  • Dorsal striatum
  • Emotional memory
  • Endocannabinoids
  • Glucocorticoids
  • Memory consolidation
  • Stress

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Siller-Pérez, C., Fuentes-Ibañez, A., Sotelo-Barrera, E. L., Serafín, N., Prado-Alcalá, R. A., Campolongo, P., ... Quirarte, G. L. (2018). Glucocorticoid interactions with the dorsal striatal endocannabinoid system in regulating inhibitory avoidance memory. Psychoneuroendocrinology, 99, 97-103. https://doi.org/10.1016/j.psyneuen.2018.08.021

Glucocorticoid interactions with the dorsal striatal endocannabinoid system in regulating inhibitory avoidance memory. / Siller-Pérez, Cristina; Fuentes-Ibañez, Antonio; Sotelo-Barrera, Erika L.; Serafín, Norma; Prado-Alcalá, Roberto A.; Campolongo, Patrizia; Roozendaal, Benno; Quirarte, Gina L.

In: Psychoneuroendocrinology, Vol. 99, 2018, p. 97-103.

Research output: Contribution to journalArticle

Siller-Pérez, C, Fuentes-Ibañez, A, Sotelo-Barrera, EL, Serafín, N, Prado-Alcalá, RA, Campolongo, P, Roozendaal, B & Quirarte, GL 2018, 'Glucocorticoid interactions with the dorsal striatal endocannabinoid system in regulating inhibitory avoidance memory', Psychoneuroendocrinology, vol. 99, pp. 97-103. https://doi.org/10.1016/j.psyneuen.2018.08.021
Siller-Pérez, Cristina ; Fuentes-Ibañez, Antonio ; Sotelo-Barrera, Erika L. ; Serafín, Norma ; Prado-Alcalá, Roberto A. ; Campolongo, Patrizia ; Roozendaal, Benno ; Quirarte, Gina L. / Glucocorticoid interactions with the dorsal striatal endocannabinoid system in regulating inhibitory avoidance memory. In: Psychoneuroendocrinology. 2018 ; Vol. 99. pp. 97-103.
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