Glucocorticoids and Th-1, Th-2 type cytokines in rheumatoid arthritis, osteoarthritis, asthma, atopic dermatitis and AIDS

G. Norbiato, M. Bevilacqua, T. Vago, M. Clerici

Research output: Contribution to journalArticle

Abstract

Endogenous or exogenous glucocorticoids play a key role in the control of the immune and inflammatory network. Regulation of the effects of the glucocorticoids depends on changes in therapeutic levels, but also, as recently discovered, on modifications of the binding characteristics of the glucocorticoid receptors of target cells. In rheumatoid arthritis (RA), chronic bronchial asthma, atopic dermatitis, in chondrocytes from osteoarthritic patients, and in advanced stages of HIV infection, there is a down-regulation of the glucocorticoid receptors. As a consequence, B cell immune proliferation is stimulated in RA, proteolysis is enhanced in osteoarthritis, the glucocorticoids' therapeutic effect is reduced in asthma and atopic dermatitis, and a chronic persistent increase of interferon α is seen in HIV. Finally, glucocorticoids are also capable of switching CD4 cells from a Th-1 to a Th-2 pattern. A decreased affinity of lymphocyte glucocorticoid receptors could hinder such a switch, with obvious clinical implications.

Original languageEnglish
Pages (from-to)315-323
Number of pages9
JournalClinical and Experimental Rheumatology
Volume15
Issue number3
Publication statusPublished - May 1997

Keywords

  • AIDS
  • Atopic dermatitis
  • Bronchial asthma
  • Cytokines of the Th- 1
  • Glucocorticoid receptor
  • Glucocorticoids
  • Osteoarthritis
  • Rheumatoid arthritis
  • Th-2-subtype-HIV

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

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