Abstract
8-Hydroxyquinolines are systems of great interest in the field of inorganic and bioinorganic chemistry. They are metal-binding compounds and are known to exhibit a variety of biological activities, such as antibacterial and anticancer activities. Among these systems, clioquinol has been the focus of a renewed interest in recent years. In this scenario, we synthesized and characterized the new clioquinol glucoconjugate, 5-chloro-7-iodo-8-quinolinyl-β-d- glucopyranoside in order to compare this system to that of clioquinol. We also synthesized, 8-quinolinyl-β-d-glucopyranoside, an 8-hydroxyquinoline glucoconjugate. The reason for the development of glucoconjugates is the glucose avidity, and the over-expression of glucose transporters in cancer cells. Here we demonstrate that glycoconjugates are cleaved in vitro by β-glucosidase and these systems exhibit antiproliferative activity against different tumor cell lines in the presence of copper(ii) ions.
Original language | English |
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Pages (from-to) | 4530-4535 |
Number of pages | 6 |
Journal | Dalton Transactions |
Volume | 41 |
Issue number | 15 |
DOIs | |
Publication status | Published - Apr 21 2012 |
ASJC Scopus subject areas
- Inorganic Chemistry