Glucose- A nd Lipid-Related Biomarkers Are Affected in Healthy Obese or Hyperglycemic Adults Consuming a Whole-Grain Pasta Enriched in Prebiotics and Probiotics: A 12-Week Randomized Controlled Trial

Donato Angelino, Alessia Martina, Alice Rosi, Licia Veronesi, Monica Antonini, Ilario Mennella, Paola Vitaglione, Sara Grioni, Furio Brighenti, Ivana Zavaroni, Clara Fares, Sandra Torriani, Nicoletta Pellegrini

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Synbiotic foods, which combine the action of prebiotics and probiotics along the gastrointestinal tract, can affect inflammatory and glucose-related markers. Objective: The aim of this study was to investigate the effects on inflammatory and glycemia-related markers of a whole-grain pasta containing barley β-glucans and Bacillus coagulans BC30, 6086 in healthy overweight or obese volunteers. Methods: A single-blind, parallel, randomized, placebo-controlled dietary intervention study was carried out. Forty-one healthy sedentary overweight (body mass index [BMI] 25-29.9 kg/m2) and obese (BMI ≥30) volunteers, aged 30-65 y and low consumers of fruit and vegetables, ate 1 serving/d of whole-grain control (CTR) or innovative (INN) pasta for 12 wk and maintained their habitual diets. Biological samples were collected at baseline and every 4 wk for primary (plasma high-sensitivity C-reactive protein [hs-CRP] and fasting plasma lipid profile) and secondary outcomes (glycemia-related markers, blood pressure, fecal microbiota composition, and body weight). Between (CTR compared with INN) and within (among weeks) group differences were tested for the whole population and for subgroups stratified by baseline values of BMI (≥30) and glycemia (≥100 mg/dL). Results: INN or CTR pasta consumption had no effect on primary and secondary outcomes over time, except for a significant increase in plasma γ-glutamyltransferase (GGT) after 12 wk of CTR pasta consumption. Comparisons between intervention groups revealed differences only at 12 wk: Plasma GGT was higher in the CTR group; plasma hs-CRP, plasma LDL/HDL cholesterol ratio, and Bifidobacterium spp. were lower in the INN subgroup of obese volunteers; plasma resistin was lower and Faecalibacterium prausnitzii abundance was higher in the INN subgroup of hyperglycemic volunteers. Conclusions: A daily serving of a synbiotic whole-grain pasta had limited effects on primary and secondary outcomes in the entire group of volunteers but affected glycemia- A nd lipid-related markers and resistin in a subgroup of healthy obese or hyperglycemic volunteers.

Original languageEnglish
Pages (from-to)1714-1723
Number of pages10
JournalJournal of Nutrition
Volume149
Issue number10
DOIs
Publication statusPublished - Oct 1 2019

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Prebiotics
compound A 12
Probiotics
Randomized Controlled Trials
Biomarkers
Volunteers
Lipids
Glucose
Synbiotics
Resistin
Body Mass Index
C-Reactive Protein
Single-Blind Method
Bifidobacterium
Glucans
Microbiota
Hordeum
Whole Grains
Vegetables
LDL Cholesterol

Keywords

  • Bacillus coagulans
  • gastrointestinal tract
  • inflammation
  • obesity
  • randomized controlled trial
  • resistin
  • whole grain
  • β-glucans
  • γ-glutamyltransferase

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Glucose- A nd Lipid-Related Biomarkers Are Affected in Healthy Obese or Hyperglycemic Adults Consuming a Whole-Grain Pasta Enriched in Prebiotics and Probiotics : A 12-Week Randomized Controlled Trial. / Angelino, Donato; Martina, Alessia; Rosi, Alice; Veronesi, Licia; Antonini, Monica; Mennella, Ilario; Vitaglione, Paola; Grioni, Sara; Brighenti, Furio; Zavaroni, Ivana; Fares, Clara; Torriani, Sandra; Pellegrini, Nicoletta.

In: Journal of Nutrition, Vol. 149, No. 10, 01.10.2019, p. 1714-1723.

Research output: Contribution to journalArticle

Angelino, D, Martina, A, Rosi, A, Veronesi, L, Antonini, M, Mennella, I, Vitaglione, P, Grioni, S, Brighenti, F, Zavaroni, I, Fares, C, Torriani, S & Pellegrini, N 2019, 'Glucose- A nd Lipid-Related Biomarkers Are Affected in Healthy Obese or Hyperglycemic Adults Consuming a Whole-Grain Pasta Enriched in Prebiotics and Probiotics: A 12-Week Randomized Controlled Trial', Journal of Nutrition, vol. 149, no. 10, pp. 1714-1723. https://doi.org/10.1093/jn/nxz071
Angelino, Donato ; Martina, Alessia ; Rosi, Alice ; Veronesi, Licia ; Antonini, Monica ; Mennella, Ilario ; Vitaglione, Paola ; Grioni, Sara ; Brighenti, Furio ; Zavaroni, Ivana ; Fares, Clara ; Torriani, Sandra ; Pellegrini, Nicoletta. / Glucose- A nd Lipid-Related Biomarkers Are Affected in Healthy Obese or Hyperglycemic Adults Consuming a Whole-Grain Pasta Enriched in Prebiotics and Probiotics : A 12-Week Randomized Controlled Trial. In: Journal of Nutrition. 2019 ; Vol. 149, No. 10. pp. 1714-1723.
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abstract = "Background: Synbiotic foods, which combine the action of prebiotics and probiotics along the gastrointestinal tract, can affect inflammatory and glucose-related markers. Objective: The aim of this study was to investigate the effects on inflammatory and glycemia-related markers of a whole-grain pasta containing barley β-glucans and Bacillus coagulans BC30, 6086 in healthy overweight or obese volunteers. Methods: A single-blind, parallel, randomized, placebo-controlled dietary intervention study was carried out. Forty-one healthy sedentary overweight (body mass index [BMI] 25-29.9 kg/m2) and obese (BMI ≥30) volunteers, aged 30-65 y and low consumers of fruit and vegetables, ate 1 serving/d of whole-grain control (CTR) or innovative (INN) pasta for 12 wk and maintained their habitual diets. Biological samples were collected at baseline and every 4 wk for primary (plasma high-sensitivity C-reactive protein [hs-CRP] and fasting plasma lipid profile) and secondary outcomes (glycemia-related markers, blood pressure, fecal microbiota composition, and body weight). Between (CTR compared with INN) and within (among weeks) group differences were tested for the whole population and for subgroups stratified by baseline values of BMI (≥30) and glycemia (≥100 mg/dL). Results: INN or CTR pasta consumption had no effect on primary and secondary outcomes over time, except for a significant increase in plasma γ-glutamyltransferase (GGT) after 12 wk of CTR pasta consumption. Comparisons between intervention groups revealed differences only at 12 wk: Plasma GGT was higher in the CTR group; plasma hs-CRP, plasma LDL/HDL cholesterol ratio, and Bifidobacterium spp. were lower in the INN subgroup of obese volunteers; plasma resistin was lower and Faecalibacterium prausnitzii abundance was higher in the INN subgroup of hyperglycemic volunteers. Conclusions: A daily serving of a synbiotic whole-grain pasta had limited effects on primary and secondary outcomes in the entire group of volunteers but affected glycemia- A nd lipid-related markers and resistin in a subgroup of healthy obese or hyperglycemic volunteers.",
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T1 - Glucose- A nd Lipid-Related Biomarkers Are Affected in Healthy Obese or Hyperglycemic Adults Consuming a Whole-Grain Pasta Enriched in Prebiotics and Probiotics

T2 - A 12-Week Randomized Controlled Trial

AU - Angelino, Donato

AU - Martina, Alessia

AU - Rosi, Alice

AU - Veronesi, Licia

AU - Antonini, Monica

AU - Mennella, Ilario

AU - Vitaglione, Paola

AU - Grioni, Sara

AU - Brighenti, Furio

AU - Zavaroni, Ivana

AU - Fares, Clara

AU - Torriani, Sandra

AU - Pellegrini, Nicoletta

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Background: Synbiotic foods, which combine the action of prebiotics and probiotics along the gastrointestinal tract, can affect inflammatory and glucose-related markers. Objective: The aim of this study was to investigate the effects on inflammatory and glycemia-related markers of a whole-grain pasta containing barley β-glucans and Bacillus coagulans BC30, 6086 in healthy overweight or obese volunteers. Methods: A single-blind, parallel, randomized, placebo-controlled dietary intervention study was carried out. Forty-one healthy sedentary overweight (body mass index [BMI] 25-29.9 kg/m2) and obese (BMI ≥30) volunteers, aged 30-65 y and low consumers of fruit and vegetables, ate 1 serving/d of whole-grain control (CTR) or innovative (INN) pasta for 12 wk and maintained their habitual diets. Biological samples were collected at baseline and every 4 wk for primary (plasma high-sensitivity C-reactive protein [hs-CRP] and fasting plasma lipid profile) and secondary outcomes (glycemia-related markers, blood pressure, fecal microbiota composition, and body weight). Between (CTR compared with INN) and within (among weeks) group differences were tested for the whole population and for subgroups stratified by baseline values of BMI (≥30) and glycemia (≥100 mg/dL). Results: INN or CTR pasta consumption had no effect on primary and secondary outcomes over time, except for a significant increase in plasma γ-glutamyltransferase (GGT) after 12 wk of CTR pasta consumption. Comparisons between intervention groups revealed differences only at 12 wk: Plasma GGT was higher in the CTR group; plasma hs-CRP, plasma LDL/HDL cholesterol ratio, and Bifidobacterium spp. were lower in the INN subgroup of obese volunteers; plasma resistin was lower and Faecalibacterium prausnitzii abundance was higher in the INN subgroup of hyperglycemic volunteers. Conclusions: A daily serving of a synbiotic whole-grain pasta had limited effects on primary and secondary outcomes in the entire group of volunteers but affected glycemia- A nd lipid-related markers and resistin in a subgroup of healthy obese or hyperglycemic volunteers.

AB - Background: Synbiotic foods, which combine the action of prebiotics and probiotics along the gastrointestinal tract, can affect inflammatory and glucose-related markers. Objective: The aim of this study was to investigate the effects on inflammatory and glycemia-related markers of a whole-grain pasta containing barley β-glucans and Bacillus coagulans BC30, 6086 in healthy overweight or obese volunteers. Methods: A single-blind, parallel, randomized, placebo-controlled dietary intervention study was carried out. Forty-one healthy sedentary overweight (body mass index [BMI] 25-29.9 kg/m2) and obese (BMI ≥30) volunteers, aged 30-65 y and low consumers of fruit and vegetables, ate 1 serving/d of whole-grain control (CTR) or innovative (INN) pasta for 12 wk and maintained their habitual diets. Biological samples were collected at baseline and every 4 wk for primary (plasma high-sensitivity C-reactive protein [hs-CRP] and fasting plasma lipid profile) and secondary outcomes (glycemia-related markers, blood pressure, fecal microbiota composition, and body weight). Between (CTR compared with INN) and within (among weeks) group differences were tested for the whole population and for subgroups stratified by baseline values of BMI (≥30) and glycemia (≥100 mg/dL). Results: INN or CTR pasta consumption had no effect on primary and secondary outcomes over time, except for a significant increase in plasma γ-glutamyltransferase (GGT) after 12 wk of CTR pasta consumption. Comparisons between intervention groups revealed differences only at 12 wk: Plasma GGT was higher in the CTR group; plasma hs-CRP, plasma LDL/HDL cholesterol ratio, and Bifidobacterium spp. were lower in the INN subgroup of obese volunteers; plasma resistin was lower and Faecalibacterium prausnitzii abundance was higher in the INN subgroup of hyperglycemic volunteers. Conclusions: A daily serving of a synbiotic whole-grain pasta had limited effects on primary and secondary outcomes in the entire group of volunteers but affected glycemia- A nd lipid-related markers and resistin in a subgroup of healthy obese or hyperglycemic volunteers.

KW - Bacillus coagulans

KW - gastrointestinal tract

KW - inflammation

KW - obesity

KW - randomized controlled trial

KW - resistin

KW - whole grain

KW - β-glucans

KW - γ-glutamyltransferase

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