Glucose-based total parenteral nutrition does not stimulate glucose uptake by humans tumours

Federico Bozzetti, Cecilia Gavazzi, Luigi Mariani, Flavio Crippa

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Since glucose represents the preferred fuel for cancer cells, there is some debate about the potential stimulation of tumour metabolism induced by a glucose-based total parenteral nutrition (TPN) in cancer patients. Methods: We investigated the uptake of [18]2-fluoro-2-deoxy-D-glucose (FDG) through the positron emission tomography of the healthy liver and of the tumour in 12 patients with liver metastases from colorectal cancer. We determined whether FDG uptake by the tumour in fasting conditions was affected by the subsequent administration of a glucose-based (GTPN) or a lipid-based (LTPN) containing glucose 4 mg/kg/min or lipid 2 mg/kg/min, respectively, as non-protein energy source. Results: The data showed that FDG uptake by the metastases was 3-3.6 times higher than by the healthy liver in fasting conditions and it was not significantly affected by the subsequent administration of GTPN or LTPN. Conclusions: We speculated that, despite glucose being the preferred fuel for cancer cells, its disproportionately high uptake even in fasting conditions makes the glucose consumption unable to be modulated by a further supply of glucose or lipid.

Original languageEnglish
Pages (from-to)417-421
Number of pages5
JournalClinical Nutrition
Volume23
Issue number3
DOIs
Publication statusPublished - Jun 2004

Keywords

  • Glucose uptake by liver cells
  • Glucose uptake by tumour
  • Glucose-based TPN
  • Lipid-based TPN

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Critical Care and Intensive Care Medicine
  • Endocrinology, Diabetes and Metabolism
  • Gastroenterology
  • Health Professions(all)

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