Glucose disposal in morbidly obese patients in the early post-operative period

Donatella Gniuli, Elisabetta Liverani, Alessandro Armuzzi, Melania Manco, Marco Castagneto, Geltrude Mingrone, Aldo V. Greco, Giovanni Gasbarrini

Research output: Contribution to journalArticlepeer-review

Abstract

Background: In surgical patients, operative stress causes protein catabolism, muscle mass loss, and impaired glucose tolerance. We investigated fuel metabolism and glucose and protein turnover in 15 obese subjects who underwent biliopancreatic diversion (BPD) by using stable labelled isotopes. Methods: 6 males and 9 females (age 45.11±8.9 years, BMI of 48.85±4.43 kg/m 2) who underwent BPD were studied, and the APACHE II score was calculated. Patients were studied 3 times (before BPD, 1st and 3rd postoperative day). Glycemia was stable - maintained by continuously infusing Rapid Insulin. Each day of the study, the patients received a primed, constant infusion of [ 15N 2] urea, and, 180 min after, a [6.6- 2H] glucose infusion started and continued for 3 hours. Indirect calorimetry was performed during the study, under TPN (30 kcal/kg). Results: The APACHE score was lower on the 3rd postoperative day than on the 1st postoperative day (7.4±2.7 vs 6.3±2.6, p

Original languageEnglish
Pages (from-to)686-692
Number of pages7
JournalObesity Surgery
Volume11
Issue number6
DOIs
Publication statusPublished - 2001

Keywords

  • [6.6- H] glucose
  • [ N ] urea
  • Bariatric surgery
  • Indirect calorimetry
  • Morbid obesity

ASJC Scopus subject areas

  • Surgery

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