Glucose-induced changes in renal haemodynamics in proteinuric Type 1 (insulin-dependent) diabetic patients: inhibition by acetylsalicilic acid infusion

S. De Cosmo, K. Earle, A. Morocutti, J. Walker, P. Ruggenenti, G. Remuzzi, G. C. Viberti

Research output: Contribution to journalArticle


The effect of hyperglycaemia on renal function in diabetic nephropathy remains poorly understood. We investigated the renal haemodynamic response to an acute plasma glucose rise from sustained euglycaemia to sustained hyperglycaemia in eight persistently proteinuric Type 1 (insulin-dependent) diabetic patients. Studies were performed in a double-blind cross-over manner after i.v. injection of 450 mg lysine acetylsalicilate (equivalent to 250 mg acetylsalicilic acid) or equal volume of 0.9% NaCl (isotonic saline). In the isotonic saline experiments hyperglycaemia produced a significant rise, by approximately 35%, in glomerular filtration rate in all patients from 41.5±5.2 to 55±6 ml·min-1·1.73 m-2 (p-1·1.73 m-2 (p-1·1.73 m-2; p-1 ·1.73 m-2; p

Original languageEnglish
Pages (from-to)622-627
Number of pages6
Issue number7
Publication statusPublished - Jul 1993



  • Diabetic nephropathy
  • hyperglycaemia
  • lysine-acetyl-salicilate
  • renal haemodynamics
  • Type 1 (insulin-dependent) diabetes mellitus

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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