TY - JOUR
T1 - Glucose ingestion affects cardiac ANS in healthy subjects with different amounts of body fat
AU - Paolisso, Giuseppe
AU - Manzella, Daniela
AU - Ferrara, Nicola
AU - Gambardella, Antonio
AU - Abete, Pasquale
AU - Tagliamonte, Maria Rosaria
AU - De Lucia, Domenico
AU - Furgi, Giuseppe
AU - Picone, Costantino
AU - Gentile, Salvatore
AU - Rengo, Franco
AU - Varricchio, Michele
PY - 1997
Y1 - 1997
N2 - Low-to-high frequency ratio (LF/HF) is an indirect index of sympathovagal balance derived by heart rate spectral analysis. We investigated the effect of glucose ingestion on LF/HF in 17 healthy, normotensive young subjects (9 male, 8 female) with a wide body fat content range (body fat = 29 ± 5.9%; range = 19-42%) and a normal thyroid hormone status. Before and after an oral glucose tolerance test (OGTT), the Holier technique and indirect calorimetry allowed us to determine heart rate and substrate oxidation in all subjects. At baseline, LF/HF correlated with body fat (r = 0.60, P <0.005), waist-to-hip ratio (r = 0.57, P <0.01), fasting plasma insulin (r = 0.55, P <0.04), leptin (r = 0.56, P <0.01 ), and norepinephrine (r = 0.58, P <0.009) concentrations. Age-, body fat-, content-, and fat-free mass-adjusted respiratory quotient (r = 0.59, P <0.007) and basal metabolic rate (r = 0.61, P <0.001) were also correlated with basal LF/HF. Along with OGTT plasma glucose, insulin and norepinephrine concentrations and basal LF/HF significantly rose at 60 min and then declined throughout the test. Area under the curve (AUC) for LF/HF correlated with body fat (r = -0.66, P <0.004), fasting plasma leptin concentration (r = -0.57, P <0.01), glucose induced thermogenesis (r = 0.62, P <0.001), glucose uptake (r = 0.59, P <0.007), and AUC for plasma norepinephrine concentration (r = 0.63, P <0.001). Water instead of glucose ingestion does not significantly affect LF/HF (n = 8). In conclusion, our study supports the hypothesis that glucose ingestion affects LF/HF and that such change is related to the amount of body fat.
AB - Low-to-high frequency ratio (LF/HF) is an indirect index of sympathovagal balance derived by heart rate spectral analysis. We investigated the effect of glucose ingestion on LF/HF in 17 healthy, normotensive young subjects (9 male, 8 female) with a wide body fat content range (body fat = 29 ± 5.9%; range = 19-42%) and a normal thyroid hormone status. Before and after an oral glucose tolerance test (OGTT), the Holier technique and indirect calorimetry allowed us to determine heart rate and substrate oxidation in all subjects. At baseline, LF/HF correlated with body fat (r = 0.60, P <0.005), waist-to-hip ratio (r = 0.57, P <0.01), fasting plasma insulin (r = 0.55, P <0.04), leptin (r = 0.56, P <0.01 ), and norepinephrine (r = 0.58, P <0.009) concentrations. Age-, body fat-, content-, and fat-free mass-adjusted respiratory quotient (r = 0.59, P <0.007) and basal metabolic rate (r = 0.61, P <0.001) were also correlated with basal LF/HF. Along with OGTT plasma glucose, insulin and norepinephrine concentrations and basal LF/HF significantly rose at 60 min and then declined throughout the test. Area under the curve (AUC) for LF/HF correlated with body fat (r = -0.66, P <0.004), fasting plasma leptin concentration (r = -0.57, P <0.01), glucose induced thermogenesis (r = 0.62, P <0.001), glucose uptake (r = 0.59, P <0.007), and AUC for plasma norepinephrine concentration (r = 0.63, P <0.001). Water instead of glucose ingestion does not significantly affect LF/HF (n = 8). In conclusion, our study supports the hypothesis that glucose ingestion affects LF/HF and that such change is related to the amount of body fat.
KW - Autonomie nervous system (ANS)
KW - Body fat content
KW - Plasma leptin levels
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M3 - Article
AN - SCOPUS:33745363872
VL - 273
JO - American Journal of Physiology
JF - American Journal of Physiology
SN - 0363-6119
IS - 3 PART 1
ER -