Glucose metabolism as a marker of myocardial ischemia

Research output: Contribution to journalArticle

Abstract

Although the heart is omnivorous, glucose becomes the key substrate under conditions of stress. The utilization of exogenous glucose by the myocardium can be assessed non-invasively using positron emission tomography (PET) with the glucose analogue 18F-fluorodeoxyglucose (FDG). Several studies have demonstrated that glucose utilization is increased at peak stress and during conditions of reduced oxygen supply. Moreover, glucose utilization remains elevated after an episode of transient ischemia, which constitutes a sort of "metabolic memory". PET with FDG also permits the identification of "hibernating myocardium". This allows a more accurate stratification of patients with post-ischemic left ventricular dysfunction and identification of those that might benefit most from coronary revascularization.

Original languageEnglish
Pages (from-to)14-18
Number of pages5
JournalHeart and Metabolism
Issue number53
Publication statusPublished - 2011

Fingerprint

Myocardial Ischemia
Glucose
Positron-Emission Tomography
Myocardium
Fluorodeoxyglucose F18
Left Ventricular Dysfunction
Ischemia
Oxygen

Keywords

  • Coronary artery disease
  • Myocardial ischemia
  • Myocardial metabolism
  • Positron emission tomography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Glucose metabolism as a marker of myocardial ischemia. / Camici, Paolo G.

In: Heart and Metabolism, No. 53, 2011, p. 14-18.

Research output: Contribution to journalArticle

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