Glucose regulation and oxidative stress in healthy centenarians

Michelangela Barbieri, Maria Rosaria Rizzo, Daniela Manzella, Rodolfo Grella, Emilia Ragno, Marco Carbonella, Angela Marie Abbatecola, Giuseppe Paolisso

Research output: Contribution to journalArticlepeer-review


Aging, oxidative stress and insulin resistance are strongly correlated. There is a growing body of evidence showing that aging is associated with a significant rise in oxidative stress mainly due to a decline in anti-oxidant activity and a rise in pro-oxidant factors such as glucose and insulin concentrations. Furthermore, aging is also associated with a progressive rise in insulin resistance which is due to a complex network of environmental, anthropometric and neuro-hormonal factors. It is noteworthy that extreme longevity, e.g. centenarians, is associated with a low degree of oxidative stress and insulin resistance. The causes for such differences between aged subjects and centenarians is not fully understood. It is likely that a specific genetic background might play a role. However, the insulin gene does not seem to be involved for explaining such age-related differences.

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalExperimental Gerontology
Issue number1-2
Publication statusPublished - Jan 2003


  • Insulin gene
  • Insulin resistance
  • Longevity
  • Oxidative stress

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)


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