Glucose regulation and oxidative stress in healthy centenarians

Michelangela Barbieri, Maria Rosaria Rizzo, Daniela Manzella, Rodolfo Grella, Emilia Ragno, Marco Carbonella, Angela Marie Abbatecola, Giuseppe Paolisso

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Aging, oxidative stress and insulin resistance are strongly correlated. There is a growing body of evidence showing that aging is associated with a significant rise in oxidative stress mainly due to a decline in anti-oxidant activity and a rise in pro-oxidant factors such as glucose and insulin concentrations. Furthermore, aging is also associated with a progressive rise in insulin resistance which is due to a complex network of environmental, anthropometric and neuro-hormonal factors. It is noteworthy that extreme longevity, e.g. centenarians, is associated with a low degree of oxidative stress and insulin resistance. The causes for such differences between aged subjects and centenarians is not fully understood. It is likely that a specific genetic background might play a role. However, the insulin gene does not seem to be involved for explaining such age-related differences.

Original languageEnglish
Pages (from-to)137-143
Number of pages7
JournalExperimental Gerontology
Volume38
Issue number1-2
DOIs
Publication statusPublished - Jan 2003

Fingerprint

Oxidative stress
Insulin Resistance
Oxidative Stress
Insulin
Glucose
Aging of materials
Oxidants
Reactive Oxygen Species
Complex networks
Genes

Keywords

  • Insulin gene
  • Insulin resistance
  • Longevity
  • Oxidative stress

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

Cite this

Barbieri, M., Rizzo, M. R., Manzella, D., Grella, R., Ragno, E., Carbonella, M., ... Paolisso, G. (2003). Glucose regulation and oxidative stress in healthy centenarians. Experimental Gerontology, 38(1-2), 137-143. https://doi.org/10.1016/S0531-5565(02)00153-5

Glucose regulation and oxidative stress in healthy centenarians. / Barbieri, Michelangela; Rizzo, Maria Rosaria; Manzella, Daniela; Grella, Rodolfo; Ragno, Emilia; Carbonella, Marco; Abbatecola, Angela Marie; Paolisso, Giuseppe.

In: Experimental Gerontology, Vol. 38, No. 1-2, 01.2003, p. 137-143.

Research output: Contribution to journalArticle

Barbieri, M, Rizzo, MR, Manzella, D, Grella, R, Ragno, E, Carbonella, M, Abbatecola, AM & Paolisso, G 2003, 'Glucose regulation and oxidative stress in healthy centenarians', Experimental Gerontology, vol. 38, no. 1-2, pp. 137-143. https://doi.org/10.1016/S0531-5565(02)00153-5
Barbieri M, Rizzo MR, Manzella D, Grella R, Ragno E, Carbonella M et al. Glucose regulation and oxidative stress in healthy centenarians. Experimental Gerontology. 2003 Jan;38(1-2):137-143. https://doi.org/10.1016/S0531-5565(02)00153-5
Barbieri, Michelangela ; Rizzo, Maria Rosaria ; Manzella, Daniela ; Grella, Rodolfo ; Ragno, Emilia ; Carbonella, Marco ; Abbatecola, Angela Marie ; Paolisso, Giuseppe. / Glucose regulation and oxidative stress in healthy centenarians. In: Experimental Gerontology. 2003 ; Vol. 38, No. 1-2. pp. 137-143.
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