Abstract
Aging, oxidative stress and insulin resistance are strongly correlated. There is a growing body of evidence showing that aging is associated with a significant rise in oxidative stress mainly due to a decline in anti-oxidant activity and a rise in pro-oxidant factors such as glucose and insulin concentrations. Furthermore, aging is also associated with a progressive rise in insulin resistance which is due to a complex network of environmental, anthropometric and neuro-hormonal factors. It is noteworthy that extreme longevity, e.g. centenarians, is associated with a low degree of oxidative stress and insulin resistance. The causes for such differences between aged subjects and centenarians is not fully understood. It is likely that a specific genetic background might play a role. However, the insulin gene does not seem to be involved for explaining such age-related differences.
| Original language | English |
|---|---|
| Pages (from-to) | 137-143 |
| Number of pages | 7 |
| Journal | Experimental Gerontology |
| Volume | 38 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Jan 2003 |
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Keywords
- Insulin gene
- Insulin resistance
- Longevity
- Oxidative stress
ASJC Scopus subject areas
- Ageing
- Medicine(all)
Cite this
Glucose regulation and oxidative stress in healthy centenarians. / Barbieri, Michelangela; Rizzo, Maria Rosaria; Manzella, Daniela; Grella, Rodolfo; Ragno, Emilia; Carbonella, Marco; Abbatecola, Angela Marie; Paolisso, Giuseppe.
In: Experimental Gerontology, Vol. 38, No. 1-2, 01.2003, p. 137-143.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Glucose regulation and oxidative stress in healthy centenarians
AU - Barbieri, Michelangela
AU - Rizzo, Maria Rosaria
AU - Manzella, Daniela
AU - Grella, Rodolfo
AU - Ragno, Emilia
AU - Carbonella, Marco
AU - Abbatecola, Angela Marie
AU - Paolisso, Giuseppe
PY - 2003/1
Y1 - 2003/1
N2 - Aging, oxidative stress and insulin resistance are strongly correlated. There is a growing body of evidence showing that aging is associated with a significant rise in oxidative stress mainly due to a decline in anti-oxidant activity and a rise in pro-oxidant factors such as glucose and insulin concentrations. Furthermore, aging is also associated with a progressive rise in insulin resistance which is due to a complex network of environmental, anthropometric and neuro-hormonal factors. It is noteworthy that extreme longevity, e.g. centenarians, is associated with a low degree of oxidative stress and insulin resistance. The causes for such differences between aged subjects and centenarians is not fully understood. It is likely that a specific genetic background might play a role. However, the insulin gene does not seem to be involved for explaining such age-related differences.
AB - Aging, oxidative stress and insulin resistance are strongly correlated. There is a growing body of evidence showing that aging is associated with a significant rise in oxidative stress mainly due to a decline in anti-oxidant activity and a rise in pro-oxidant factors such as glucose and insulin concentrations. Furthermore, aging is also associated with a progressive rise in insulin resistance which is due to a complex network of environmental, anthropometric and neuro-hormonal factors. It is noteworthy that extreme longevity, e.g. centenarians, is associated with a low degree of oxidative stress and insulin resistance. The causes for such differences between aged subjects and centenarians is not fully understood. It is likely that a specific genetic background might play a role. However, the insulin gene does not seem to be involved for explaining such age-related differences.
KW - Insulin gene
KW - Insulin resistance
KW - Longevity
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=0037237370&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037237370&partnerID=8YFLogxK
U2 - 10.1016/S0531-5565(02)00153-5
DO - 10.1016/S0531-5565(02)00153-5
M3 - Article
C2 - 12543271
AN - SCOPUS:0037237370
VL - 38
SP - 137
EP - 143
JO - Experimental Gerontology
JF - Experimental Gerontology
SN - 0531-5565
IS - 1-2
ER -