Glucose transportation in the brain and its impairment in Huntington disease: one more shade of the energetic metabolism failure?

Veronica Morea, Eris Bidollari, Gianni Colotti, Annarita Fiorillo, Jessica Rosati, Lidia De Filippis, Ferdinando Squitieri, Andrea Ilari

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Huntington’s disease (HD) or Huntington’s chorea is the most common inherited, dominantly transmitted, neurodegenerative disorder. It is caused by increased CAG repeats number in the gene coding for huntingtin (Htt) and characterized by motor, behaviour and psychiatric symptoms, ultimately leading to death. HD patients also exhibit alterations in glucose and energetic metabolism, which result in pronounced weight loss despite sustained calorie intake. Glucose metabolism decreases in the striatum of all the subjects with mutated Htt, but affects symptom presentation only when it drops below a specific threshold. Recent evidence points at defects in glucose uptake by the brain, and especially by neurons, as a relevant component of central glucose hypometabolism in HD patients. Here we review the main features of glucose metabolism and transport in the brain in physiological conditions and how these processes are impaired in HD, and discuss the potential ability of strategies aimed at increasing intracellular energy levels to counteract neurological and motor degeneration in HD patients.

Original languageEnglish
Pages (from-to)1147-1157
Number of pages11
JournalAmino Acids
Volume49
Issue number7
DOIs
Publication statusPublished - Jul 1 2017

Fingerprint

Huntington Disease
Metabolism
Brain
Glucose
Physiological Phenomena
Aptitude
Electron energy levels
Neurons
Neurodegenerative Diseases
Genes
Psychiatry
Weight Loss
Defects

Keywords

  • Energetic metabolism
  • Glucose transport
  • GLUT1
  • GLUT3
  • Huntington disease

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Glucose transportation in the brain and its impairment in Huntington disease : one more shade of the energetic metabolism failure? / Morea, Veronica; Bidollari, Eris; Colotti, Gianni; Fiorillo, Annarita; Rosati, Jessica; De Filippis, Lidia; Squitieri, Ferdinando; Ilari, Andrea.

In: Amino Acids, Vol. 49, No. 7, 01.07.2017, p. 1147-1157.

Research output: Contribution to journalReview article

Morea, Veronica ; Bidollari, Eris ; Colotti, Gianni ; Fiorillo, Annarita ; Rosati, Jessica ; De Filippis, Lidia ; Squitieri, Ferdinando ; Ilari, Andrea. / Glucose transportation in the brain and its impairment in Huntington disease : one more shade of the energetic metabolism failure?. In: Amino Acids. 2017 ; Vol. 49, No. 7. pp. 1147-1157.
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