Glutamate-induced long-term potentiation of the frequency of miniature synaptic currents in cultured hippocampal neurons

Antonio Malgaroli, Richard W. Tsien

Research output: Contribution to journalArticlepeer-review

Abstract

Glutamate application at synapses between hippocampal neurons in culture produces long-term potentiation of the frequency of spontaneous miniature synaptic currents, together with long-term potentiation of evoked synaptic currents. The mini frequency potentiation is initiated postsynaptically and requires activity of NMDA receptors. Although the frequency of unitary quantal responses increases strongly, their amplitude remains little changed with potentiation. Tests of postsynaptic responsiveness rule out recruitment of latent glutamate receptor clusters. Thus, postsynaptic induction can lead to enhancement of presynaptic transmitter release. The sustained potentiation of mini frequency is expressed even in the absence of Ca2+ entry into presynaptic terminals.

Original languageEnglish
Pages (from-to)134-139
Number of pages6
JournalNature
Volume357
Issue number6374
Publication statusPublished - May 14 1992

ASJC Scopus subject areas

  • General

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