Glutamate receptors in striatum and substantia nigra: Effects of medial forebrain bundle lesions

Ullrich Wüllner, Claudia M. Testa, Maria Vincenza Catania, Anne B. Young, John B. Penney

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

We examined NMDA-sensitive [3H]glutamate, [3H]AMPA, [3H]kainate and metabotropic-sensitive [3H]glutamate binding sites in neostriatum and substantia nigra pars reticulata (SNr) in rats after unilateral 6-hydroxydopamine lesions of the medial forebrain bundle. One week after the lesion, NMDA, AMPA, kainate and metabotropic receptors were decreased in the ipsilateral neostriatum, whereas at three months NMDA receptors were increased while AMPA, kainate and metabotropic receptors were not changed. In the SNr at one week, only AMPA and metabotropic receptors were significantly decreased whereas three months after the lesion NMDA, AMPA and kainate binding sites were decreased. The early decrease of excitatory amino acid receptors in the striatum is likely to reflect degeneration of dopaminergic fibers, suggesting that specific subpopulations of excitatory amino acid binding sites are located on dopaminergic terminals.

Original languageEnglish
Pages (from-to)98-102
Number of pages5
JournalBrain Research
Volume645
Issue number1-2
DOIs
Publication statusPublished - May 9 1994

Fingerprint

Medial Forebrain Bundle
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Glutamate Receptors
Substantia Nigra
N-Methylaspartate
Neostriatum
Kainic Acid Receptors
Kainic Acid
Binding Sites
Glutamic Acid
Excitatory Amino Acids
AMPA Receptors
Oxidopamine
N-Methyl-D-Aspartate Receptors
Pars Reticulata

Keywords

  • 6-Hydroxydopamine
  • Autoradiography
  • Glutamate receptor
  • Parkinson's disease
  • Striatum
  • Substantia nigra

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Wüllner, U., Testa, C. M., Catania, M. V., Young, A. B., & Penney, J. B. (1994). Glutamate receptors in striatum and substantia nigra: Effects of medial forebrain bundle lesions. Brain Research, 645(1-2), 98-102. https://doi.org/10.1016/0006-8993(94)91642-X

Glutamate receptors in striatum and substantia nigra : Effects of medial forebrain bundle lesions. / Wüllner, Ullrich; Testa, Claudia M.; Catania, Maria Vincenza; Young, Anne B.; Penney, John B.

In: Brain Research, Vol. 645, No. 1-2, 09.05.1994, p. 98-102.

Research output: Contribution to journalArticle

Wüllner, U, Testa, CM, Catania, MV, Young, AB & Penney, JB 1994, 'Glutamate receptors in striatum and substantia nigra: Effects of medial forebrain bundle lesions', Brain Research, vol. 645, no. 1-2, pp. 98-102. https://doi.org/10.1016/0006-8993(94)91642-X
Wüllner, Ullrich ; Testa, Claudia M. ; Catania, Maria Vincenza ; Young, Anne B. ; Penney, John B. / Glutamate receptors in striatum and substantia nigra : Effects of medial forebrain bundle lesions. In: Brain Research. 1994 ; Vol. 645, No. 1-2. pp. 98-102.
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