Glutamate uptake is decreased in platelets from Alzheimer's disease patients

Carlo Ferrarese, Barbara Begni, Carla Canevari, Chiara Zoia, Roberto Piolti, Maura Frigo, Ildebrando Appollonio, Lodovico Frattola

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Because excitotoxicity may be involved in neurodegeneration in Alzheimer's disease, we investigated possible modifications of platelet glutamate uptake in AD patients. High-affinity glutamate uptake was studied in platelets from 35 Alzheimer's disease patients, 10 multi-infarct dementia patients, and 35 age-matched normal controls; it was decreased by 40% in platelets from Alzheimer's disease patients compared with controls and with multi-infarct dementia patients. Platelet glutamate uptake could be used as peripheral marker of glutamatergic involvement and as adjunctive diagnostic tool in Alzheimer's disease patients.

Original languageEnglish
Pages (from-to)641-643
Number of pages3
JournalAnnals of Neurology
Volume47
Issue number5
DOIs
Publication statusPublished - 2000

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Glutamic Acid
Alzheimer Disease
Blood Platelets
Multi-Infarct Dementia

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ferrarese, C., Begni, B., Canevari, C., Zoia, C., Piolti, R., Frigo, M., ... Frattola, L. (2000). Glutamate uptake is decreased in platelets from Alzheimer's disease patients. Annals of Neurology, 47(5), 641-643. https://doi.org/10.1002/1531-8249(200005)47:5<641::AID-ANA12>3.0.CO;2-I

Glutamate uptake is decreased in platelets from Alzheimer's disease patients. / Ferrarese, Carlo; Begni, Barbara; Canevari, Carla; Zoia, Chiara; Piolti, Roberto; Frigo, Maura; Appollonio, Ildebrando; Frattola, Lodovico.

In: Annals of Neurology, Vol. 47, No. 5, 2000, p. 641-643.

Research output: Contribution to journalArticle

Ferrarese, C, Begni, B, Canevari, C, Zoia, C, Piolti, R, Frigo, M, Appollonio, I & Frattola, L 2000, 'Glutamate uptake is decreased in platelets from Alzheimer's disease patients', Annals of Neurology, vol. 47, no. 5, pp. 641-643. https://doi.org/10.1002/1531-8249(200005)47:5<641::AID-ANA12>3.0.CO;2-I
Ferrarese, Carlo ; Begni, Barbara ; Canevari, Carla ; Zoia, Chiara ; Piolti, Roberto ; Frigo, Maura ; Appollonio, Ildebrando ; Frattola, Lodovico. / Glutamate uptake is decreased in platelets from Alzheimer's disease patients. In: Annals of Neurology. 2000 ; Vol. 47, No. 5. pp. 641-643.
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