Glutamic acid and sodium levels in the nucleus arcuatus of the hypothalamus of adult and infant guinea pigs after oral monosodium glutamate

L. Airoldi, S. Garattini

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Monosodium glutamate (MSG) administered orally at 4 g/kg body weight (b.wt.) as a 20% solution (w/v) to 55-60-day-old guinea pigs and at 2 g/kg b.wt. as a 20% solution (w/v) to 3-day-old guinea pigs did not increase glutamie acid (GA) or sodium levels in the nucleus arcuatus of the hypothalamus (NAH) or in the thalamus lateralis (TL). Sodium chloride given by gavage at doses of sodium equimolar to MSG resulted in an increase of sodium content only in the NAH of infant guinea pigs.

Original languageEnglish
Pages (from-to)313-316
Number of pages4
JournalToxicology Letters
Volume4
Issue number4
DOIs
Publication statusPublished - 1979

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Sodium Glutamate
Hypothalamus
Glutamic Acid
Guinea Pigs
Sodium
Body Weight
Thalamus
Sodium Chloride
Acids

ASJC Scopus subject areas

  • Toxicology

Cite this

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author = "L. Airoldi and S. Garattini",
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T1 - Glutamic acid and sodium levels in the nucleus arcuatus of the hypothalamus of adult and infant guinea pigs after oral monosodium glutamate

AU - Airoldi, L.

AU - Garattini, S.

PY - 1979

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N2 - Monosodium glutamate (MSG) administered orally at 4 g/kg body weight (b.wt.) as a 20% solution (w/v) to 55-60-day-old guinea pigs and at 2 g/kg b.wt. as a 20% solution (w/v) to 3-day-old guinea pigs did not increase glutamie acid (GA) or sodium levels in the nucleus arcuatus of the hypothalamus (NAH) or in the thalamus lateralis (TL). Sodium chloride given by gavage at doses of sodium equimolar to MSG resulted in an increase of sodium content only in the NAH of infant guinea pigs.

AB - Monosodium glutamate (MSG) administered orally at 4 g/kg body weight (b.wt.) as a 20% solution (w/v) to 55-60-day-old guinea pigs and at 2 g/kg b.wt. as a 20% solution (w/v) to 3-day-old guinea pigs did not increase glutamie acid (GA) or sodium levels in the nucleus arcuatus of the hypothalamus (NAH) or in the thalamus lateralis (TL). Sodium chloride given by gavage at doses of sodium equimolar to MSG resulted in an increase of sodium content only in the NAH of infant guinea pigs.

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