Glutamine-supplemented total parenteral nutrition improves immunological status in anorectic patients

Stefania Mondello, Domenico Italiano, Maria Stella Giacobbe, Patrizia Mondello, Giuseppe Trimarchi, Carmela Aloisi, Placido Bramanti, Edoardo Spina

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: Glutamine is an important substrate for critical cells of the immune system, in particular lymphocytes and macrophages, and it is considered a conditionally essential amino acid. Several studies have indicated that glutamine-enriched total parenteral nutrition improves immunologic status and shortens length of stay of critically ill patients. We investigated the effect of total parenteral nutrition supplemented with glutamine on the immune system in anorectic patients. Methods: Thirty-six anorectic patients were randomized to receive standard parenteral nutrition or parenteral nutrition supplemented with glutamine 0.18 g · kg-1 · d-1 for 20 d. To evaluate the immune system status, we determined serum levels of neopterin and insulin growth factor-1 and lymphocyte count at baseline and after 10 and 20 d from the beginning of the therapy. Results and Conclusions: The results showed a significant increase of the serum levels of neopterin after 10 d of treatment with glutamine (26.44 ± 3.08 versus 6.75 ± 1.73 nmol/L, P <0.001), thus proving a probable stimulating action carried out by glutamine on the immune system, as testified by the increase of lymphocytes.

Original languageEnglish
Pages (from-to)677-681
Number of pages5
JournalNutrition
Volume26
Issue number6
DOIs
Publication statusPublished - Jun 2010

Fingerprint

Appetite Depressants
Total Parenteral Nutrition
Glutamine
Immune System
Neopterin
Parenteral Nutrition
Lymphocytes
Essential Amino Acids
Lymphocyte Count
Serum
Critical Illness
Length of Stay
Intercellular Signaling Peptides and Proteins
Macrophages
Insulin
Therapeutics

Keywords

  • Anorexia nervosa
  • Glutamine
  • Immunologic status
  • Neopterin
  • Total parenteral nutrition

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Medicine(all)

Cite this

Mondello, S., Italiano, D., Giacobbe, M. S., Mondello, P., Trimarchi, G., Aloisi, C., ... Spina, E. (2010). Glutamine-supplemented total parenteral nutrition improves immunological status in anorectic patients. Nutrition, 26(6), 677-681. https://doi.org/10.1016/j.nut.2009.10.008

Glutamine-supplemented total parenteral nutrition improves immunological status in anorectic patients. / Mondello, Stefania; Italiano, Domenico; Giacobbe, Maria Stella; Mondello, Patrizia; Trimarchi, Giuseppe; Aloisi, Carmela; Bramanti, Placido; Spina, Edoardo.

In: Nutrition, Vol. 26, No. 6, 06.2010, p. 677-681.

Research output: Contribution to journalArticle

Mondello, S, Italiano, D, Giacobbe, MS, Mondello, P, Trimarchi, G, Aloisi, C, Bramanti, P & Spina, E 2010, 'Glutamine-supplemented total parenteral nutrition improves immunological status in anorectic patients', Nutrition, vol. 26, no. 6, pp. 677-681. https://doi.org/10.1016/j.nut.2009.10.008
Mondello S, Italiano D, Giacobbe MS, Mondello P, Trimarchi G, Aloisi C et al. Glutamine-supplemented total parenteral nutrition improves immunological status in anorectic patients. Nutrition. 2010 Jun;26(6):677-681. https://doi.org/10.1016/j.nut.2009.10.008
Mondello, Stefania ; Italiano, Domenico ; Giacobbe, Maria Stella ; Mondello, Patrizia ; Trimarchi, Giuseppe ; Aloisi, Carmela ; Bramanti, Placido ; Spina, Edoardo. / Glutamine-supplemented total parenteral nutrition improves immunological status in anorectic patients. In: Nutrition. 2010 ; Vol. 26, No. 6. pp. 677-681.
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