TY - JOUR
T1 - GLUTAMITALY 2003
T2 - Consensus Paper SINPE sull'impiego della glutamina nella nutrizione artificiale dell'adulto
AU - Braga, M.
AU - Muscaritoli, M.
AU - Pittiruti, M.
AU - Biffi, Roberto
AU - Biolo, Gianni
AU - Bobbio Pallavicini, Franco
AU - Bossola, Maurizio
AU - Bozzetti, Federico
AU - Candusso, Manila
AU - Carideo, Pietro
AU - Contaldo, Franco
AU - Cozzaglio, Luca
AU - DeGaudio, A. Raffaele
AU - Ficari, Ferdinando
AU - Gallitelli, Livia
AU - Gavazzi, Cecilia
AU - Giacosa, Attilio
AU - Gianotti, Luca
AU - Guglielmi, Francesco W.
AU - Laviano, Alessandro
AU - Paccagnella, Agostino
AU - Palmo, Augusta
AU - Pironi, Loris
AU - Radrizzani, Danilo
AU - Salis, Carlo
AU - Sukkar, Samir G.
AU - Uderzo, Cornelio
AU - Vannucci, Andrea
AU - Zanello, Marco
PY - 2004/7
Y1 - 2004/7
N2 - From among the several nutrients believed to exert pharmacological actions, the amino acid Glutamine (GLN) is by far the most extensively studied during the last fifteen years. As an example, more than 970 papers appeared in Medline® between 1990 and 2003, matching the terms glutamine and nutrition, more than 300 of which in the form of review articles. The interest for this 'conditionallly essential' amino acid stems from the observation that it fulfills a number of biochemical needs. It operates as a nitrogen shuttle, may contribute to the formation of other amino acids, glucose, nucleotides, protein and glutathione, and represents the primary energy fuel for rapidly dividing cells, such as enterocytes, lymphocytes, macrophages and fibroblasts. In situations where a certain tissue is in greater need of GLN, inter-organ transfer of GLN usually fulfills site-specific requirements. Under certain conditions, however, endogenous GLN synthesis is not adequate to satisfy tissue needs and exogenous supplementation becomes necessary. Although exogenous parenteral and enteral GLN administation has been proven safe in the clinical setting, precise guidelines and recommendations for its use in clinical practice are still lacking, due to the non univocal interpretation of the clinical trials so far performed. The present article represents the Consensus Paper based on the results of the Glutamitaly 2003 SINPE Consensus Meeting on GLN in adult artificial nutrition. Rationale of use, indications, results of available clinical trials on GLN supplementation have been critically reviewed by a board of experts in the field of clinical nutrition with the aim to develop the methodology for possible future clinical trials evaluating the efficacy of parenteral or entreral GLN supplementation in surgery, ICU, gastroenterology, oncology and haematology patients.
AB - From among the several nutrients believed to exert pharmacological actions, the amino acid Glutamine (GLN) is by far the most extensively studied during the last fifteen years. As an example, more than 970 papers appeared in Medline® between 1990 and 2003, matching the terms glutamine and nutrition, more than 300 of which in the form of review articles. The interest for this 'conditionallly essential' amino acid stems from the observation that it fulfills a number of biochemical needs. It operates as a nitrogen shuttle, may contribute to the formation of other amino acids, glucose, nucleotides, protein and glutathione, and represents the primary energy fuel for rapidly dividing cells, such as enterocytes, lymphocytes, macrophages and fibroblasts. In situations where a certain tissue is in greater need of GLN, inter-organ transfer of GLN usually fulfills site-specific requirements. Under certain conditions, however, endogenous GLN synthesis is not adequate to satisfy tissue needs and exogenous supplementation becomes necessary. Although exogenous parenteral and enteral GLN administation has been proven safe in the clinical setting, precise guidelines and recommendations for its use in clinical practice are still lacking, due to the non univocal interpretation of the clinical trials so far performed. The present article represents the Consensus Paper based on the results of the Glutamitaly 2003 SINPE Consensus Meeting on GLN in adult artificial nutrition. Rationale of use, indications, results of available clinical trials on GLN supplementation have been critically reviewed by a board of experts in the field of clinical nutrition with the aim to develop the methodology for possible future clinical trials evaluating the efficacy of parenteral or entreral GLN supplementation in surgery, ICU, gastroenterology, oncology and haematology patients.
KW - Artificial nutrition
KW - Consensus
KW - Gastroenterology
KW - Glutamine
KW - Oncology
KW - SINPE
KW - Surgery ICU
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UR - http://www.scopus.com/inward/citedby.url?scp=19944395163&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:19944395163
VL - 22
SP - 115
EP - 133
JO - Rivista Italiana di Nutrizione Parenterale ed Enterale
JF - Rivista Italiana di Nutrizione Parenterale ed Enterale
SN - 0393-5582
IS - 3
ER -