Glutathione and nitric oxide: Key team players in use and disuse of skeletal muscle

Research output: Contribution to journalReview articlepeer-review

Abstract

Glutathione (GSH) is the main non-enzymatic antioxidant playing an important role in detoxification, signal transduction by modulation of protein thiols redox status and direct scavenging of radicals. The latter function is not only performed against reactive oxygen species (ROS) but GSH also has a fundamental role in buffering nitric oxide (NO), a physiologically-produced molecule having-multifaceted functions. The efficient rate of GSH synthesis and high levels of GSH-dependent enzymes are characteristic features of healthy skeletal muscle where, besides the canonical functions, it is also involved in muscle contraction regulation. Moreover, NO production in skeletal muscle is a direct consequence of contractile activity and influences several metabolic myocyte pathways under both physiological and pathological conditions. In this review, we will consider the homeostasis and intersection of GSH with NO and then we will restrict the discussion on their role in processes related to skeletal muscle function and degeneration.

Original languageEnglish
Article number2318
JournalNutrients
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 2019

Keywords

  • Atrophy
  • Exercise
  • Inflammation
  • Nitrosative stress
  • Oxidative stress

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Glutathione and nitric oxide: Key team players in use and disuse of skeletal muscle'. Together they form a unique fingerprint.

Cite this