Glutathione metabolism and antioxidant enzymes in children with Down syndrome

Anna Pastore, Giulia Tozzi, Laura Maria Gaeta, Aldo Giannotti, Enrico Bertini, Giorgio Federici, Maria Cristina Digilio, Fiorella Piemonte

Research output: Contribution to journalArticle

Abstract

Oxidative stress has been proposed as a pathogenic mechanism of atherosclerosis, cell aging, and neurologic disorders in Down syndrome. This study demonstrates a systemic decrease of all glutathione forms, including glutathionyl-hemoglobin, in the blood of children with Down syndrome. Furthermore, we obtained a disequilibrium, in vivo, between the antioxidant enzyme activities.

Original languageEnglish
Pages (from-to)583-585
Number of pages3
JournalJournal of Pediatrics
Volume142
Issue number5
DOIs
Publication statusPublished - May 1 2003

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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