Glutathione: New roles in redox signalling for an old antioxidant

Katia Aquilano, Sara Baldelli, Maria R. Ciriolo

Research output: Contribution to journalArticlepeer-review


The physiological roles played by the tripeptide glutathione have greatly advanced over the past decades superimposing the research on free radicals, oxidative stress and, more recently, redox signalling. In particular, GSH is involved in nutrient metabolism, antioxidant defence and regulation of cellular metabolic functions ranging from gene expression, DNA and protein synthesis to signal transduction, cell proliferation and apoptosis. This review will be focused on the role of GSH in cell signalling by analysing the more recent advancements about its capability to modulate nitroxidative stress, autophagy and viral infection.

Original languageEnglish
Article numberArticle 196
JournalFrontiers in Pharmacology
Volume5 AUG
Publication statusPublished - 2014


  • Autophagy
  • Nitric oxide
  • Reactive oxygen species
  • Redox signal
  • Viral infection

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology


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