TY - JOUR
T1 - Glutathione
T2 - New roles in redox signalling for an old antioxidant
AU - Aquilano, Katia
AU - Baldelli, Sara
AU - Ciriolo, Maria R.
PY - 2014
Y1 - 2014
N2 - The physiological roles played by the tripeptide glutathione have greatly advanced over the past decades superimposing the research on free radicals, oxidative stress and, more recently, redox signalling. In particular, GSH is involved in nutrient metabolism, antioxidant defence and regulation of cellular metabolic functions ranging from gene expression, DNA and protein synthesis to signal transduction, cell proliferation and apoptosis. This review will be focused on the role of GSH in cell signalling by analysing the more recent advancements about its capability to modulate nitroxidative stress, autophagy and viral infection.
AB - The physiological roles played by the tripeptide glutathione have greatly advanced over the past decades superimposing the research on free radicals, oxidative stress and, more recently, redox signalling. In particular, GSH is involved in nutrient metabolism, antioxidant defence and regulation of cellular metabolic functions ranging from gene expression, DNA and protein synthesis to signal transduction, cell proliferation and apoptosis. This review will be focused on the role of GSH in cell signalling by analysing the more recent advancements about its capability to modulate nitroxidative stress, autophagy and viral infection.
KW - Autophagy
KW - Nitric oxide
KW - Reactive oxygen species
KW - Redox signal
KW - Viral infection
UR - http://www.scopus.com/inward/record.url?scp=84906239247&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84906239247&partnerID=8YFLogxK
U2 - 10.3389/fphar.2014.00196
DO - 10.3389/fphar.2014.00196
M3 - Article
AN - SCOPUS:84906239247
VL - 5 AUG
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
SN - 1663-9812
M1 - Article 196
ER -