Abstract
Glutathione (GSH), glutathione S-transferase (GST) activity and GSTπ expression were measured in 10 human bladder tumors and adjacent uninvolved specimens from Egyptian patients with a history of schistosomal infection. GSH was higher in the tumor than in surrounding uninvolved tissue (not significant). Total GST activity per mg tissue protein and GSTπ expression were higher in tumor tissues (P <0.05) than in uninvolved tissues. There was a positive correlation between GST activity and GSH content and between total GST activity and GSTπ expression in both tumor and uninvolved tissues.
| Original language | English |
|---|---|
| Pages (from-to) | 19-23 |
| Number of pages | 5 |
| Journal | Cancer Letters |
| Volume | 121 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Dec 16 1997 |
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Keywords
- Bladder neoplasms
- Glutathione
- Glutathione transferases
- Schistosomiasis
ASJC Scopus subject areas
- Cancer Research
- Molecular Biology
- Oncology
Cite this
Glutathione S-transferase activity and glutathione content in human bladder carcinoma associated with schistosomiasis : Comparison with uninvolved surrounding tissues. / Hassan, Ashraf A M; Tagliabue, Giovanna; Codegoni, Anna Maria; D'Incalci, Maurizio; El-Sewedy, Shehata M.; Airoldi, Luisa.
In: Cancer Letters, Vol. 121, No. 1, 16.12.1997, p. 19-23.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Glutathione S-transferase activity and glutathione content in human bladder carcinoma associated with schistosomiasis
T2 - Comparison with uninvolved surrounding tissues
AU - Hassan, Ashraf A M
AU - Tagliabue, Giovanna
AU - Codegoni, Anna Maria
AU - D'Incalci, Maurizio
AU - El-Sewedy, Shehata M.
AU - Airoldi, Luisa
PY - 1997/12/16
Y1 - 1997/12/16
N2 - Glutathione (GSH), glutathione S-transferase (GST) activity and GSTπ expression were measured in 10 human bladder tumors and adjacent uninvolved specimens from Egyptian patients with a history of schistosomal infection. GSH was higher in the tumor than in surrounding uninvolved tissue (not significant). Total GST activity per mg tissue protein and GSTπ expression were higher in tumor tissues (P <0.05) than in uninvolved tissues. There was a positive correlation between GST activity and GSH content and between total GST activity and GSTπ expression in both tumor and uninvolved tissues.
AB - Glutathione (GSH), glutathione S-transferase (GST) activity and GSTπ expression were measured in 10 human bladder tumors and adjacent uninvolved specimens from Egyptian patients with a history of schistosomal infection. GSH was higher in the tumor than in surrounding uninvolved tissue (not significant). Total GST activity per mg tissue protein and GSTπ expression were higher in tumor tissues (P <0.05) than in uninvolved tissues. There was a positive correlation between GST activity and GSH content and between total GST activity and GSTπ expression in both tumor and uninvolved tissues.
KW - Bladder neoplasms
KW - Glutathione
KW - Glutathione transferases
KW - Schistosomiasis
UR - http://www.scopus.com/inward/record.url?scp=0030734154&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030734154&partnerID=8YFLogxK
U2 - 10.1016/S0304-3835(97)00314-5
DO - 10.1016/S0304-3835(97)00314-5
M3 - Article
VL - 121
SP - 19
EP - 23
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 1
ER -