Abstract
Glutathione (GSH), glutathione S-transferase (GST) activity and GSTπ expression were measured in 10 human bladder tumors and adjacent uninvolved specimens from Egyptian patients with a history of schistosomal infection. GSH was higher in the tumor than in surrounding uninvolved tissue (not significant). Total GST activity per mg tissue protein and GSTπ expression were higher in tumor tissues (P <0.05) than in uninvolved tissues. There was a positive correlation between GST activity and GSH content and between total GST activity and GSTπ expression in both tumor and uninvolved tissues.
Original language | English |
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Pages (from-to) | 19-23 |
Number of pages | 5 |
Journal | Cancer Letters |
Volume | 121 |
Issue number | 1 |
DOIs | |
Publication status | Published - Dec 16 1997 |
Keywords
- Bladder neoplasms
- Glutathione
- Glutathione transferases
- Schistosomiasis
ASJC Scopus subject areas
- Cancer Research
- Molecular Biology
- Oncology