Glutathione S-transferase activity and glutathione content in human bladder carcinoma associated with schistosomiasis: Comparison with uninvolved surrounding tissues

Ashraf A M Hassan; Giovanna Tagliabue; Anna Maria Codegoni; Maurizio D'Incalci; Shehata M. El-Sewedy; Luisa Airoldi

doi:10.1016/S0304-3835(97)00314-5

Glutathione S-transferase activity and glutathione content in human bladder carcinoma associated with schistosomiasis: Comparison with uninvolved surrounding tissues

Ashraf A M Hassan, Giovanna Tagliabue, Anna Maria Codegoni, Maurizio D'Incalci, Shehata M. El-Sewedy, Luisa Airoldi

Research output: Contribution to journal › Article › peer-review

Abstract

Glutathione (GSH), glutathione S-transferase (GST) activity and GSTπ expression were measured in 10 human bladder tumors and adjacent uninvolved specimens from Egyptian patients with a history of schistosomal infection. GSH was higher in the tumor than in surrounding uninvolved tissue (not significant). Total GST activity per mg tissue protein and GSTπ expression were higher in tumor tissues (P <0.05) than in uninvolved tissues. There was a positive correlation between GST activity and GSH content and between total GST activity and GSTπ expression in both tumor and uninvolved tissues.

Original language	English
Pages (from-to)	19-23
Number of pages	5
Journal	Cancer Letters
Volume	121
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3835(97)00314-5
Publication status	Published - Dec 16 1997

Keywords

Bladder neoplasms
Glutathione
Glutathione transferases
Schistosomiasis

ASJC Scopus subject areas

Cancer Research
Molecular Biology
Oncology

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10.1016/S0304-3835(97)00314-5

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title = "Glutathione S-transferase activity and glutathione content in human bladder carcinoma associated with schistosomiasis: Comparison with uninvolved surrounding tissues",

abstract = "Glutathione (GSH), glutathione S-transferase (GST) activity and GSTπ expression were measured in 10 human bladder tumors and adjacent uninvolved specimens from Egyptian patients with a history of schistosomal infection. GSH was higher in the tumor than in surrounding uninvolved tissue (not significant). Total GST activity per mg tissue protein and GSTπ expression were higher in tumor tissues (P <0.05) than in uninvolved tissues. There was a positive correlation between GST activity and GSH content and between total GST activity and GSTπ expression in both tumor and uninvolved tissues.",

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T1 - Glutathione S-transferase activity and glutathione content in human bladder carcinoma associated with schistosomiasis

T2 - Comparison with uninvolved surrounding tissues

AU - Hassan, Ashraf A M

AU - Tagliabue, Giovanna

AU - Codegoni, Anna Maria

AU - D'Incalci, Maurizio

AU - El-Sewedy, Shehata M.

AU - Airoldi, Luisa

PY - 1997/12/16

Y1 - 1997/12/16

N2 - Glutathione (GSH), glutathione S-transferase (GST) activity and GSTπ expression were measured in 10 human bladder tumors and adjacent uninvolved specimens from Egyptian patients with a history of schistosomal infection. GSH was higher in the tumor than in surrounding uninvolved tissue (not significant). Total GST activity per mg tissue protein and GSTπ expression were higher in tumor tissues (P <0.05) than in uninvolved tissues. There was a positive correlation between GST activity and GSH content and between total GST activity and GSTπ expression in both tumor and uninvolved tissues.

AB - Glutathione (GSH), glutathione S-transferase (GST) activity and GSTπ expression were measured in 10 human bladder tumors and adjacent uninvolved specimens from Egyptian patients with a history of schistosomal infection. GSH was higher in the tumor than in surrounding uninvolved tissue (not significant). Total GST activity per mg tissue protein and GSTπ expression were higher in tumor tissues (P <0.05) than in uninvolved tissues. There was a positive correlation between GST activity and GSH content and between total GST activity and GSTπ expression in both tumor and uninvolved tissues.

KW - Bladder neoplasms

KW - Glutathione

KW - Glutathione transferases

KW - Schistosomiasis

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Glutathione S-transferase activity and glutathione content in human bladder carcinoma associated with schistosomiasis: Comparison with uninvolved surrounding tissues

Abstract

Keywords

ASJC Scopus subject areas

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