Glutathione-S-transferase genotypes influence prognosis in follicular non-Hodgkin's Lymphoma

Stefan Hohaus, Giovanna Mansueto, Giuseppina Massini, Francesco D'Alo, Manuela Giachelia, Maurizio Martini, Luigi Maria Larocca, Maria Teresa Voso, Giuseppe Leone

Research output: Contribution to journalArticlepeer-review

Abstract

Polymorphisms in detoxification enzymes of the glutathione S-transferase (GST) family have been associated with risk and prognosis of several cancer types. We studied deletions of GSTM1 and GSTT1, and the GSTP1 Ile105Val polymorphism in 89 patients with follicular lymphoma (FL). Patients with a GSTM1 or GSTT1 deletion had a significantly worse event-free survival, when compared with patients with undeleted genotype (p = 0.03 and p = 0.03, respectively). Outcome was even worse in patients with a double negative genotype, in comparison with patients with only one GST deletion or normal genotype (p = 0.01). In the multivariate analysis, the GSTM1/GSTT1 genotype tended to have a prognostic significance independent from the Follicular Lymphoma International Prognostic Index (FLIPI) score. In particular, GSTM1/T1 deletions identified patients with negative prognosis in the low (

Original languageEnglish
Pages (from-to)564-569
Number of pages6
JournalLeukemia and Lymphoma
Volume48
Issue number3
DOIs
Publication statusPublished - Mar 2007

Keywords

  • Follicular NHL
  • Genetic susceptibility
  • GST
  • Polymorphism
  • Prognostic factors

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Fingerprint Dive into the research topics of 'Glutathione-S-transferase genotypes influence prognosis in follicular non-Hodgkin's Lymphoma'. Together they form a unique fingerprint.

Cite this