Glutathione S-Transferase (GST) polymorphisms as risk factors for cancer in a highly homogeneous population from Southern Italy

Alessandro Sgambato, Biagina Campisi, Angela Zupa, Annamaria Bochicchio, Gianpiero Romano, Alfredo Tartarone, Rocco Galasso, Antonio Traficante, Achille Cittadini

Research output: Contribution to journalArticle

Abstract

Glutathione S-Transferase (GST) is a phase II enzyme and catalyses reactions between glutathione and a variety of electrophilic compounds, including some environmental carcinogens. In man, at least 20 isoenzymatic forms of GST have been identified and many of them show genetically-based individual variability of enzyme activity. The GSTM1 and GSTT1 isoenzymes display several polymorphisms, including a homozygotic deletion, which have been associated with an increased risk for developing neoplastic diseases. There is geographical and ethnic variation in genotype frequencies for both genes. The available data suggest that cancer incidence varies amongst Italian regions, being higher in Northern that in Southern areas, though it is unknown whether this phenomenon is to be attributed to genetic and/or environmental factors. We performed a case-control study to evaluate the GSTM1 and GSTT1 polymorphisms in a series of cancer patients in Basilicata, a Southern Italian region, and in corresponding controls. The results obtained demonstrate that the occurrence of GST polymorphisms in the Basilicata population is not different from other Italian regions and suggest that the population attributable risk associated with these genotypes may be quite high. GSTM1 homozygous null genotype was associated with an increasing risk of cancer, especially in females. The strongest association was with colon and breast cancers. For the GSTT1 gene, the results obtained were suggestive of a decreased risk of cancer associated with the null genotype. Thus, similar studies on these and other susceptibility genes are warranted since they can help to identify susceptible subgroups of people who can be targeted for cancer prevention.

Original languageEnglish
Pages (from-to)3647-3652
Number of pages6
JournalAnticancer Research
Volume22
Issue number6 B
Publication statusPublished - Nov 2002

    Fingerprint

Keywords

  • Cancer susceptibility
  • Colorectal cancer
  • Epidemiology
  • Glutathione S-Transferase (GST)
  • GSTM1
  • GSTT1
  • Southern Italy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Sgambato, A., Campisi, B., Zupa, A., Bochicchio, A., Romano, G., Tartarone, A., Galasso, R., Traficante, A., & Cittadini, A. (2002). Glutathione S-Transferase (GST) polymorphisms as risk factors for cancer in a highly homogeneous population from Southern Italy. Anticancer Research, 22(6 B), 3647-3652.