Glutathione S-transferase P1-1 involvement during apoptosis induced by H2O2 and etoposide

S. Bernardini, F. Bernassola, C. Cortese, S. Ballerini, G. Melino, C. Motti, L. Bellincampi, R. Iori, G. Federici

Research output: Contribution to journalArticle

Abstract

The finding that glutathione S-transferase (GST) P1-1 might inhibit JNK activity, as recently described, and that it is frequently highly expressed in tumor tissues suggests its possible implication in 'apoptosis-resistance' during antineoplastic therapy. We studied the modulation of GST P1-1 expression, activity and polymerization during apoptosis induced by H2O2 and etoposide in T Jurkat cell line. Our data seem to suggest that H2O2 and etoposide may act through a process of partial inactivation of the GST P1-1, possibly involving the 'G' site in the process of dimerization, thus favoring programmed cell death.

Original languageEnglish
Pages (from-to)308-311
Number of pages4
JournalChemico-Biological Interactions
Volume133
Issue number1-3
Publication statusPublished - Feb 28 2001

Fingerprint

Glutathione S-Transferase pi
Etoposide
Glutathione Transferase
Apoptosis
Jurkat Cells
Dimerization
Cell death
Polymerization
Antineoplastic Agents
Tumors
Cell Death
Cells
Modulation
Tissue
Cell Line
Neoplasms
Therapeutics

Keywords

  • Etoposide
  • Glutathione transferase P1-1
  • Hydrogen peroxide

ASJC Scopus subject areas

  • Toxicology

Cite this

Bernardini, S., Bernassola, F., Cortese, C., Ballerini, S., Melino, G., Motti, C., ... Federici, G. (2001). Glutathione S-transferase P1-1 involvement during apoptosis induced by H2O2 and etoposide. Chemico-Biological Interactions, 133(1-3), 308-311.

Glutathione S-transferase P1-1 involvement during apoptosis induced by H2O2 and etoposide. / Bernardini, S.; Bernassola, F.; Cortese, C.; Ballerini, S.; Melino, G.; Motti, C.; Bellincampi, L.; Iori, R.; Federici, G.

In: Chemico-Biological Interactions, Vol. 133, No. 1-3, 28.02.2001, p. 308-311.

Research output: Contribution to journalArticle

Bernardini, S, Bernassola, F, Cortese, C, Ballerini, S, Melino, G, Motti, C, Bellincampi, L, Iori, R & Federici, G 2001, 'Glutathione S-transferase P1-1 involvement during apoptosis induced by H2O2 and etoposide', Chemico-Biological Interactions, vol. 133, no. 1-3, pp. 308-311.
Bernardini S, Bernassola F, Cortese C, Ballerini S, Melino G, Motti C et al. Glutathione S-transferase P1-1 involvement during apoptosis induced by H2O2 and etoposide. Chemico-Biological Interactions. 2001 Feb 28;133(1-3):308-311.
Bernardini, S. ; Bernassola, F. ; Cortese, C. ; Ballerini, S. ; Melino, G. ; Motti, C. ; Bellincampi, L. ; Iori, R. ; Federici, G. / Glutathione S-transferase P1-1 involvement during apoptosis induced by H2O2 and etoposide. In: Chemico-Biological Interactions. 2001 ; Vol. 133, No. 1-3. pp. 308-311.
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