Abstract
Purpose: The aim of this pilot study was to assess the association between polymorphisms in genes that encode for proteins involved in the pharmacokinetics/pharmacodynamics of glucocorticoids and the occurrence of respiratory distress syndrome (RDS) in preterm infants born to mothers treated with a complete course of betamethasone. Methods: Sixty-two preterm infants were enrolled. The C1236T, G2677T, and C3435T polymorphisms in the ABCB1 gene, BclI, N363S and ER22/23EK in the NR3C1 gene, I105V in the GST-P1 gene and GST-M1 and GST-T1 deletions were analyzed, and their association with the occurrence of RDS was assessed. Results: In univariate analysis, the heterozygous and homozygous presence of the I105V variant in the GST-P1 gene seemed to confer protection against the occurrence of RDS (P∈=∈0.032), while no association for all other polymorphisms was observed. In multivariate analysis, selection from the reference model of independent variables based on AIC (Akaike information criteria) maintained three variables in the model: gestation, C3435T, and GST-P1 genotype. Conclusions: Polymorphisms of the GST-P1 gene may influence the effect of antenatal steroids on the newborn lung.
| Original language | English |
|---|---|
| Pages (from-to) | 483-491 |
| Number of pages | 9 |
| Journal | European Journal of Clinical Pharmacology |
| Volume | 65 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2009 |
Fingerprint
Keywords
- ATP binding cassette, subfamily B, member 1 (ABCB1)
- Glucocorticoids
- Glutathione-S-transferase (GST)
- Nuclear receptor subfamily 3, group C, member 1 (NR3C1)
- Respiratory distress syndrome
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology
Cite this
Glutathione-S-transferase-P1 I105V polymorphism and response to antenatal betamethasone in the prevention of respiratory distress syndrome. / Oretti, Chiara; Marino, Sara; Mosca, Fabio; Colnaghi, Maria Rosa; De Iudicibus, Sara; Drigo, Ilenia; Stocco, Gabriele; Bartoli, Fiora; Decorti, Giuliana; Demarini, Sergio.
In: European Journal of Clinical Pharmacology, Vol. 65, No. 5, 05.2009, p. 483-491.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Glutathione-S-transferase-P1 I105V polymorphism and response to antenatal betamethasone in the prevention of respiratory distress syndrome
AU - Oretti, Chiara
AU - Marino, Sara
AU - Mosca, Fabio
AU - Colnaghi, Maria Rosa
AU - De Iudicibus, Sara
AU - Drigo, Ilenia
AU - Stocco, Gabriele
AU - Bartoli, Fiora
AU - Decorti, Giuliana
AU - Demarini, Sergio
PY - 2009/5
Y1 - 2009/5
N2 - Purpose: The aim of this pilot study was to assess the association between polymorphisms in genes that encode for proteins involved in the pharmacokinetics/pharmacodynamics of glucocorticoids and the occurrence of respiratory distress syndrome (RDS) in preterm infants born to mothers treated with a complete course of betamethasone. Methods: Sixty-two preterm infants were enrolled. The C1236T, G2677T, and C3435T polymorphisms in the ABCB1 gene, BclI, N363S and ER22/23EK in the NR3C1 gene, I105V in the GST-P1 gene and GST-M1 and GST-T1 deletions were analyzed, and their association with the occurrence of RDS was assessed. Results: In univariate analysis, the heterozygous and homozygous presence of the I105V variant in the GST-P1 gene seemed to confer protection against the occurrence of RDS (P∈=∈0.032), while no association for all other polymorphisms was observed. In multivariate analysis, selection from the reference model of independent variables based on AIC (Akaike information criteria) maintained three variables in the model: gestation, C3435T, and GST-P1 genotype. Conclusions: Polymorphisms of the GST-P1 gene may influence the effect of antenatal steroids on the newborn lung.
AB - Purpose: The aim of this pilot study was to assess the association between polymorphisms in genes that encode for proteins involved in the pharmacokinetics/pharmacodynamics of glucocorticoids and the occurrence of respiratory distress syndrome (RDS) in preterm infants born to mothers treated with a complete course of betamethasone. Methods: Sixty-two preterm infants were enrolled. The C1236T, G2677T, and C3435T polymorphisms in the ABCB1 gene, BclI, N363S and ER22/23EK in the NR3C1 gene, I105V in the GST-P1 gene and GST-M1 and GST-T1 deletions were analyzed, and their association with the occurrence of RDS was assessed. Results: In univariate analysis, the heterozygous and homozygous presence of the I105V variant in the GST-P1 gene seemed to confer protection against the occurrence of RDS (P∈=∈0.032), while no association for all other polymorphisms was observed. In multivariate analysis, selection from the reference model of independent variables based on AIC (Akaike information criteria) maintained three variables in the model: gestation, C3435T, and GST-P1 genotype. Conclusions: Polymorphisms of the GST-P1 gene may influence the effect of antenatal steroids on the newborn lung.
KW - ATP binding cassette, subfamily B, member 1 (ABCB1)
KW - Glucocorticoids
KW - Glutathione-S-transferase (GST)
KW - Nuclear receptor subfamily 3, group C, member 1 (NR3C1)
KW - Respiratory distress syndrome
UR - http://www.scopus.com/inward/record.url?scp=67349104142&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349104142&partnerID=8YFLogxK
U2 - 10.1007/s00228-009-0617-8
DO - 10.1007/s00228-009-0617-8
M3 - Article
C2 - 19183974
AN - SCOPUS:67349104142
VL - 65
SP - 483
EP - 491
JO - European Journal of Clinical Pharmacology
JF - European Journal of Clinical Pharmacology
SN - 0031-6970
IS - 5
ER -