Abstract
Background: Oxidative stress and neuronal cell death have been implicated in the pathogenesis of Alzheimer disease (AD). Considering that the glutathiqne transferase (GST) supergene family encodes isoenzymes that appear to be critical in protection against oxidative stress, we aimed at determining the various GSTP1, GSTM1, and GSTT1 polymorphisms and ApoE geno-types to investigate their role as susceptibility genes for late-onset AD (LOAD). Methods: We included 210 LOAD patients and 228 healthy controls matched for age, sex, and educational level in our case-control genetic association study. GSTM1 and GSTT1 genotypes were studied by conventional PCR, whereas GSTP1 and ApoE genotypes were determined by real-time PCR on the LightCycler. Results: We found a significant association between LOAD and the GSTP1*C allelic variant [odds ratio (OR) = 1.9; P
| Original language | English |
|---|---|
| Pages (from-to) | 944-951 |
| Number of pages | 8 |
| Journal | Clinical Chemistry |
| Volume | 51 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2005 |
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ASJC Scopus subject areas
- Clinical Biochemistry
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Glutathione S-transferase PI *C allelic variant increases susceptibility for late-onset Alzheimer disease : Association study and relationship with apolipoprotein E ε4 allele. / Bernardini, Sergio; Bellincampi, Lorenza; Ballerini, Sabrina; Federici, Giorgio; Iori, Roberta; Trequattrini, Alberto; Ciappi, Fabrizio; Baldinetti, Francesca; Bossù, Paola; Caltagirone, Carlo; Spalletta, Gianfranco.
In: Clinical Chemistry, Vol. 51, No. 6, 06.2005, p. 944-951.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Glutathione S-transferase PI *C allelic variant increases susceptibility for late-onset Alzheimer disease
T2 - Association study and relationship with apolipoprotein E ε4 allele
AU - Bernardini, Sergio
AU - Bellincampi, Lorenza
AU - Ballerini, Sabrina
AU - Federici, Giorgio
AU - Iori, Roberta
AU - Trequattrini, Alberto
AU - Ciappi, Fabrizio
AU - Baldinetti, Francesca
AU - Bossù, Paola
AU - Caltagirone, Carlo
AU - Spalletta, Gianfranco
PY - 2005/6
Y1 - 2005/6
N2 - Background: Oxidative stress and neuronal cell death have been implicated in the pathogenesis of Alzheimer disease (AD). Considering that the glutathiqne transferase (GST) supergene family encodes isoenzymes that appear to be critical in protection against oxidative stress, we aimed at determining the various GSTP1, GSTM1, and GSTT1 polymorphisms and ApoE geno-types to investigate their role as susceptibility genes for late-onset AD (LOAD). Methods: We included 210 LOAD patients and 228 healthy controls matched for age, sex, and educational level in our case-control genetic association study. GSTM1 and GSTT1 genotypes were studied by conventional PCR, whereas GSTP1 and ApoE genotypes were determined by real-time PCR on the LightCycler. Results: We found a significant association between LOAD and the GSTP1*C allelic variant [odds ratio (OR) = 1.9; P
AB - Background: Oxidative stress and neuronal cell death have been implicated in the pathogenesis of Alzheimer disease (AD). Considering that the glutathiqne transferase (GST) supergene family encodes isoenzymes that appear to be critical in protection against oxidative stress, we aimed at determining the various GSTP1, GSTM1, and GSTT1 polymorphisms and ApoE geno-types to investigate their role as susceptibility genes for late-onset AD (LOAD). Methods: We included 210 LOAD patients and 228 healthy controls matched for age, sex, and educational level in our case-control genetic association study. GSTM1 and GSTT1 genotypes were studied by conventional PCR, whereas GSTP1 and ApoE genotypes were determined by real-time PCR on the LightCycler. Results: We found a significant association between LOAD and the GSTP1*C allelic variant [odds ratio (OR) = 1.9; P
UR - http://www.scopus.com/inward/record.url?scp=21144447584&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=21144447584&partnerID=8YFLogxK
U2 - 10.1373/clinchem.2004.045955
DO - 10.1373/clinchem.2004.045955
M3 - Article
C2 - 15805147
AN - SCOPUS:21144447584
VL - 51
SP - 944
EP - 951
JO - Clinical Chemistry
JF - Clinical Chemistry
SN - 0009-9147
IS - 6
ER -