Glutathione S-transferase PI *C allelic variant increases susceptibility for late-onset Alzheimer disease: Association study and relationship with apolipoprotein E ε4 allele

Sergio Bernardini; Lorenza Bellincampi; Sabrina Ballerini; Giorgio Federici; Roberta Iori; Alberto Trequattrini; Fabrizio Ciappi; Francesca Baldinetti; Paola Bossù; Carlo Caltagirone; Gianfranco Spalletta

doi:10.1373/clinchem.2004.045955

Glutathione S-transferase PI *C allelic variant increases susceptibility for late-onset Alzheimer disease: Association study and relationship with apolipoprotein E ε4 allele

Sergio Bernardini, Lorenza Bellincampi, Sabrina Ballerini, Giorgio Federici, Roberta Iori, Alberto Trequattrini, Fabrizio Ciappi, Francesca Baldinetti, Paola Bossù, Carlo Caltagirone, Gianfranco Spalletta

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Oxidative stress and neuronal cell death have been implicated in the pathogenesis of Alzheimer disease (AD). Considering that the glutathiqne transferase (GST) supergene family encodes isoenzymes that appear to be critical in protection against oxidative stress, we aimed at determining the various GSTP1, GSTM1, and GSTT1 polymorphisms and ApoE geno-types to investigate their role as susceptibility genes for late-onset AD (LOAD). Methods: We included 210 LOAD patients and 228 healthy controls matched for age, sex, and educational level in our case-control genetic association study. GSTM1 and GSTT1 genotypes were studied by conventional PCR, whereas GSTP1 and ApoE genotypes were determined by real-time PCR on the LightCycler. Results: We found a significant association between LOAD and the GSTP1*C allelic variant [odds ratio (OR) = 1.9; P

Original language	English
Pages (from-to)	944-951
Number of pages	8
Journal	Clinical Chemistry
Volume	51
Issue number	6
DOIs	https://doi.org/10.1373/clinchem.2004.045955
Publication status	Published - Jun 2005

ASJC Scopus subject areas

Clinical Biochemistry

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Bernardini, S., Bellincampi, L., Ballerini, S., Federici, G., Iori, R., Trequattrini, A., Ciappi, F., Baldinetti, F., Bossù, P., Caltagirone, C., & Spalletta, G. (2005). Glutathione S-transferase PI *C allelic variant increases susceptibility for late-onset Alzheimer disease: Association study and relationship with apolipoprotein E ε4 allele. Clinical Chemistry, 51(6), 944-951. https://doi.org/10.1373/clinchem.2004.045955

Glutathione S-transferase PI *C allelic variant increases susceptibility for late-onset Alzheimer disease : Association study and relationship with apolipoprotein E ε4 allele. / Bernardini, Sergio; Bellincampi, Lorenza; Ballerini, Sabrina; Federici, Giorgio; Iori, Roberta; Trequattrini, Alberto; Ciappi, Fabrizio; Baldinetti, Francesca; Bossù, Paola ; Caltagirone, Carlo ; Spalletta, Gianfranco.

In: Clinical Chemistry, Vol. 51, No. 6, 06.2005, p. 944-951.

Research output: Contribution to journal › Article › peer-review

Bernardini, S, Bellincampi, L, Ballerini, S, Federici, G, Iori, R, Trequattrini, A, Ciappi, F, Baldinetti, F, Bossù, P , Caltagirone, C & Spalletta, G 2005, 'Glutathione S-transferase PI *C allelic variant increases susceptibility for late-onset Alzheimer disease: Association study and relationship with apolipoprotein E ε4 allele', Clinical Chemistry, vol. 51, no. 6, pp. 944-951. https://doi.org/10.1373/clinchem.2004.045955

Bernardini, Sergio ; Bellincampi, Lorenza ; Ballerini, Sabrina ; Federici, Giorgio ; Iori, Roberta ; Trequattrini, Alberto ; Ciappi, Fabrizio ; Baldinetti, Francesca ; Bossù, Paola ; Caltagirone, Carlo ; Spalletta, Gianfranco. / Glutathione S-transferase PI *C allelic variant increases susceptibility for late-onset Alzheimer disease : Association study and relationship with apolipoprotein E ε4 allele. In: Clinical Chemistry. 2005 ; Vol. 51, No. 6. pp. 944-951.

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abstract = "Background: Oxidative stress and neuronal cell death have been implicated in the pathogenesis of Alzheimer disease (AD). Considering that the glutathiqne transferase (GST) supergene family encodes isoenzymes that appear to be critical in protection against oxidative stress, we aimed at determining the various GSTP1, GSTM1, and GSTT1 polymorphisms and ApoE geno-types to investigate their role as susceptibility genes for late-onset AD (LOAD). Methods: We included 210 LOAD patients and 228 healthy controls matched for age, sex, and educational level in our case-control genetic association study. GSTM1 and GSTT1 genotypes were studied by conventional PCR, whereas GSTP1 and ApoE genotypes were determined by real-time PCR on the LightCycler. Results: We found a significant association between LOAD and the GSTP1*C allelic variant [odds ratio (OR) = 1.9; P ",

author = "Sergio Bernardini and Lorenza Bellincampi and Sabrina Ballerini and Giorgio Federici and Roberta Iori and Alberto Trequattrini and Fabrizio Ciappi and Francesca Baldinetti and Paola Boss{\`u} and Carlo Caltagirone and Gianfranco Spalletta",

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AU - Bernardini, Sergio

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AU - Ballerini, Sabrina

AU - Federici, Giorgio

AU - Iori, Roberta

AU - Trequattrini, Alberto

AU - Ciappi, Fabrizio

AU - Baldinetti, Francesca

AU - Bossù, Paola

AU - Caltagirone, Carlo

AU - Spalletta, Gianfranco

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AB - Background: Oxidative stress and neuronal cell death have been implicated in the pathogenesis of Alzheimer disease (AD). Considering that the glutathiqne transferase (GST) supergene family encodes isoenzymes that appear to be critical in protection against oxidative stress, we aimed at determining the various GSTP1, GSTM1, and GSTT1 polymorphisms and ApoE geno-types to investigate their role as susceptibility genes for late-onset AD (LOAD). Methods: We included 210 LOAD patients and 228 healthy controls matched for age, sex, and educational level in our case-control genetic association study. GSTM1 and GSTT1 genotypes were studied by conventional PCR, whereas GSTP1 and ApoE genotypes were determined by real-time PCR on the LightCycler. Results: We found a significant association between LOAD and the GSTP1*C allelic variant [odds ratio (OR) = 1.9; P

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