Glutathione transferase P1 polymorphism in neuroblastoma studied by endonuclease restriction mapping

L. Bellincampi, S. Ballerini, S. Bernardini, A. Inserra, P. Marchetti, C. Boglino, A. Donfrancesco, G. Federici

Research output: Contribution to journalArticle

Abstract

Several members of the different glutathione transferase (GST) gene classes are polymorphic. Particular interest has been focused on the GSTP class because this gene class is up-regulated during the early stage of oncogenesis and is significantly overexpressed in many human tumors. It has also been shown that high levels of GSTP1 expression are associated directly with tumor drug resistance and with poor patient survival. Our aim was to understand the possible association between GSTP1 polymorphism and cellular response to chemotherapeutic drugs in neuroblastoma. In fact, several antineoplastic drugs used in the neuroblastoma high-risk chemotherapeutic protocol are potential substrates of GSTP1-1 (etoposide, adriamycin and carboplatin). The GSTP1 genotype homozygote *A/*A was identified in 11 patients independent of their response to the chemotherapeutic treatment. Only four patients had a heterozygote genotype A*/B*. Therefore, based on our preliminary data, we were not able to conclude that GSTP1 polymorphism had an impact on patient response to treatment in neuroblastoma.

Original languageEnglish
Pages (from-to)830-835
Number of pages6
JournalClinical Chemistry and Laboratory Medicine
Volume39
Issue number9
DOIs
Publication statusPublished - 2001

Keywords

  • Glutathione transferase P1-1
  • Neuroblastoma
  • Polymorphism

ASJC Scopus subject areas

  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Glutathione transferase P1 polymorphism in neuroblastoma studied by endonuclease restriction mapping'. Together they form a unique fingerprint.

  • Cite this

    Bellincampi, L., Ballerini, S., Bernardini, S., Inserra, A., Marchetti, P., Boglino, C., Donfrancesco, A., & Federici, G. (2001). Glutathione transferase P1 polymorphism in neuroblastoma studied by endonuclease restriction mapping. Clinical Chemistry and Laboratory Medicine, 39(9), 830-835. https://doi.org/10.1515/CCLM.2001.138